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Cardiovascular risk prevalence in South Africans with drug-resistant tuberculosis: a cross-sectional study

Whitehouse, E. R. ; Perrin, N. ; Levitt, N. ; Hill, M. ; Farley, J. E.

The international journal of tuberculosis and lung disease, 2019-05, Vol.23 (5), p.587-593 [Revista revisada por pares]

France: International Union Against Tuberculosis and Lung Disease

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Cardiovascular risk prevalence in South Africans with drug-resistant tuberculosis: a cross-sectional study
Autor: Whitehouse, E. R. ; Perrin, N. ; Levitt, N. ; Hill, M. ; Farley, J. E.
Materias: Adult ; Body mass ; Body mass index ; Body size ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Risk Score ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Direct reduction ; Dr-Tb ; Drug resistance ; Female ; Health risk assessment ; Health risks ; HIV ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Hypertension ; Male ; Middle Aged ; Patients ; Risk analysis ; Risk Factors ; Smoking ; South Africa - epidemiology ; Tuberculosis ; Tuberculosis, Multidrug-Resistant - epidemiology ; Viruses ; Young Adult
Es parte de: The international journal of tuberculosis and lung disease, 2019-05, Vol.23 (5), p.587-593
Notas: 1027-3719(20190501)23:5L.587;1-
(R) Medicine - General
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descripción: BACKGROUND: In South Africa, the risk factors for cardiovascular disease (CVD) are increasing, thereby impacting patients with drug-resistant tuberculosis (DR-TB).OBJECTIVE: To determine the prevalence of traditional CVD risk factors (diabetes mellitus [DM], smoking, hypertension, increased body mass index [BMI]) and a total risk score for CVD among patients with DR-TB.METHODS: This cross-sectional study was nested within an ongoing cluster-randomized trial in 10 DR-TB hospitals in South Africa. The data for the present study were collected between November 2014 and July 2016.RESULTS: Of 900 participants aged 18 years, 75.1% were co-infected with the human immunodeficiency virus (HIV), and 52.3% had one or more CVD risk factors. The prevalence of CVD risk factors was hypertension (16.7%), increased BMI (16.6%), DM (5.2%), and smoking (31.4%). Among patients with DM or hypertension, 58.8-95.5% had additional comorbid CVD risk factors. Of 398 participants eligible for the CVD risk score (age 35 years), 23.4% had a moderate or high CVD risk score.CONCLUSION: Patients with multiple diseases, including DR-TB and HIV, with traditional CVD risk factors, may have higher risks for negative outcomes during treatment for DR-TB. TB providers should identify people at risk to initiate primary and secondary prevention to improve outcomes.
Editor: France: International Union Against Tuberculosis and Lung Disease
Idioma: Inglés

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Cardiovascular risk prevalence in South Africans with drug-resistant tuberculosis: a cross-sectional study

Whitehouse, E. R. ; Perrin, N. ; Levitt, N. ; Hill, M. ; Farley, J. E.

France: International Union Against Tuberculosis and Lung Disease

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