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Survival and Allograft Rejection Rates after Combined Heart and Kidney Transplantation in Comparison with Heart Transplantation Alone

Czer, L.S.C ; Ruzza, A ; Vespignani, R ; Jordan, S ; De Robertis, M.A ; Mirocha, J ; Gallagher, S.P ; Patel, K ; Schwarz, E.R ; Kass, R.M ; Trento, A

Transplantation proceedings, 2011-12, Vol.43 (10), p.3869-3876 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

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Título:
Survival and Allograft Rejection Rates after Combined Heart and Kidney Transplantation in Comparison with Heart Transplantation Alone
Autor: Czer, L.S.C ; Ruzza, A ; Vespignani, R ; Jordan, S ; De Robertis, M.A ; Mirocha, J ; Gallagher, S.P ; Patel, K ; Schwarz, E.R ; Kass, R.M ; Trento, A
Assuntos: Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chi-Square Distribution ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - immunology ; Graft Rejection - mortality ; Heart Failure - complications ; Heart Failure - mortality ; Heart Failure - surgery ; Heart Transplantation - adverse effects ; Heart Transplantation - immunology ; Heart Transplantation - mortality ; Humans ; Kaplan-Meier Estimate ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - mortality ; Kidney Failure, Chronic - surgery ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Kidney Transplantation - mortality ; Los Angeles ; Male ; Medical sciences ; Middle Aged ; Patient Selection ; Risk Assessment ; Risk Factors ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Surgery of the urinary system ; Survival Rate ; Time Factors ; Tissue, organ and graft immunology ; Transplantation, Homologous ; Treatment Outcome ; Young Adult
É parte de: Transplantation proceedings, 2011-12, Vol.43 (10), p.3869-3876
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SourceType-Scholarly Journals-1
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Descrição: Abstract Background The role of solid multiorgan transplantation remains to be determined. We compared our experience with combined heart-kidney transplantation (HKT) and heart transplant alone (HT), and assessed patient survival rates and freedom from allograft rejection in these two patient groups. Methods We reviewed the clinical outcomes of patients undergoing HKT (n = 30) or HT (n = 440) between June 1992 and March 2009. Baseline patient characteristics, perioperative factors, incidence of rejection, and survival were examined. Results There were no significant differences between the two groups for age, gender, etiology of heart disease, functional class, preoperative left ventricular ejection fraction, end-diastolic diameter, cardiac output, or transplant waitlist status. Patients with HKT had a higher serum creatinine level ( P < .001) and a greater incidence of hypertension ( P = .04). No differences were found in cardiac allograft ischemic times, including cardiopulmonary bypass or cross-clamp times. Kidney allograft ischemic time was 14.6 ± 9 hours (mean ± SD; range, 4 hours to 49 hours). Kaplan-Meier survival estimates were similar for the HKT and HT groups at 30 days (93% ± 4.6% versus 98% ± 0.7%), 1 year (87% ± 6.2% versus 93% ± 1.2%), 5 years (68% ± 9.0% versus 76% ± 2.1%), and 10 years (51% ± 11% versus 53% ± 3.0%; P = .54 for all comparisons). Follow-up serum creatinine levels were similar after HKT and HT at 30 days (1.6 ± 1.8 mg/dL versus 1.1 ± 0.4 mg/dL), 1 year (1.4 ± 0.6 mg/dL versus 1.5 ± 0.6 mg/dL), and 5 years (1.8 ± 1.8 mg/dL versus 1.8 ± 1.2 mg/dL; P > .05 for all comparisons). Conclusions HKT offers excellent survival and similar renal function when compared with HT alone. Patients with end-stage cardiac and renal failure can be considered for HKT.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

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Survival and Allograft Rejection Rates after Combined Heart and Kidney Transplantation in Comparison with Heart Transplantation Alone

Czer, L.S.C ; Ruzza, A ; Vespignani, R ; Jordan, S ; De Robertis, M.A ; Mirocha, J ; Gallagher, S.P ; Patel, K ; Schwarz, E.R ; Kass, R.M ; Trento, A

Amsterdam: Elsevier Inc

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