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Insights into the impact of Ivermectin on some protein aspects linked to Culex pipiens digestion and immunity

Abdeltawab, Magda Said A. ; Rifaie, S. A. ; Shoeib, E. Y. ; El-Latif, H. A. Abd ; Badawi, M. ; Salama, W. H. ; El-Aal, A. A. Abd

Parasitology research (1987), 2020, Vol.119 (1), p.55-62 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Insights into the impact of Ivermectin on some protein aspects linked to Culex pipiens digestion and immunity
Autor: Abdeltawab, Magda Said A. ; Rifaie, S. A. ; Shoeib, E. Y. ; El-Latif, H. A. Abd ; Badawi, M. ; Salama, W. H. ; El-Aal, A. A. Abd
Assuntos: Animals ; Antibiotics ; Arthropods and Medical Entomology - Original Paper ; Bax protein ; bcl-2-Associated X Protein - biosynthesis ; Biomedical and Life Sciences ; Biomedicine ; Caspase 3 - biosynthesis ; Caspase-3 ; Chloride channels ; Chloride Channels - drug effects ; Cost control ; Culex - drug effects ; Culex - immunology ; Culex - physiology ; Culex pipiens ; Developing countries ; Digestion - drug effects ; Ethylenediaminetetraacetic acid ; Feeding ; Immunity - drug effects ; Immunology ; Insect Proteins - biosynthesis ; Insecticides - pharmacology ; Ivermectin ; Ivermectin - pharmacology ; LDCs ; Lipid peroxidation ; Medical Microbiology ; Microbiology ; Mosquito Vectors - drug effects ; Mosquito Vectors - physiology ; p53 Protein ; Parasitic diseases ; Physiological aspects ; Proteases ; Proteinase ; STAT Transcription Factors - biosynthesis ; Tumor proteins ; Tumor Suppressor Protein p53 - biosynthesis ; Vectors
É parte de: Parasitology research (1987), 2020, Vol.119 (1), p.55-62
Descrição: In developing countries, low-cost control and treatment programs that offer combined approaches against diseases and their vectors are certainly needed. Ivermectin (IVM) has been well known for its role in the treatment of parasitic diseases, due to its effect on glutamate-gated chloride channels. These same channels are also present in the mosquito vector, and thus, research has focused on the insecticidal effects of this drug. Possible alternative mechanisms of IVM on the physiology of mosquitoes, however, have not been sufficiently elaborated. We assessed the protease activity, lipid peroxidation, and local expression of STAT, p53, caspase-3, and Bax markers to study the effect of this antibiotic on digestion and immunity in Culex pipiens . Sugar- and blood-feeding assays were employed to investigate the potential influence of blood feeding on the dynamics of these parameters. IVM was found to have an effect on protease activity, lipid peroxidation as well as the expression of different markers investigated in this work. The focus on the detailed effect of this drug certainly opens the gate to broadening the spectrum of IVM and expanding its health and economic benefit, especially that it is relatively more affordable than other antibiotics on the market.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Insights into the impact of Ivermectin on some protein aspects linked to Culex pipiens digestion and immunity

Abdeltawab, Magda Said A. ; Rifaie, S. A. ; Shoeib, E. Y. ; El-Latif, H. A. Abd ; Badawi, M. ; Salama, W. H. ; El-Aal, A. A. Abd

Berlin/Heidelberg: Springer Berlin Heidelberg

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