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Breast cancer: Biology, biomarkers, and treatments

Barzaman, Khadijeh ; Karami, Jafar ; Zarei, Zeinab ; Hosseinzadeh, Aysooda ; Kazemi, Mohammad Hossein ; Moradi-Kalbolandi, Shima ; Safari, Elahe ; Farahmand, Leila

International immunopharmacology, 2020-07, Vol.84, p.106535-106535, Article 106535 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Breast cancer: Biology, biomarkers, and treatments
Autor: Barzaman, Khadijeh ; Karami, Jafar ; Zarei, Zeinab ; Hosseinzadeh, Aysooda ; Kazemi, Mohammad Hossein ; Moradi-Kalbolandi, Shima ; Safari, Elahe ; Farahmand, Leila
Assuntos: Albumins ; Animals ; Antibodies ; Antibody-drug conjugation systems ; Antineoplastic Agents - therapeutic use ; Biomarkers ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast cancer stem cells ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Conjugation ; Environmental factors ; Female ; Humans ; Immunotherapy ; Lipids ; Micelles ; Nanoparticles ; Polymers ; Stem cells ; Treatment ; Tumors
É parte de: International immunopharmacology, 2020-07, Vol.84, p.106535-106535, Article 106535
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: •BCSCs are the most critical cells leading to chemo and radio-resistance in tumor therapy.•Signaling pathways/metabolic components in BCSC could be targeted as a promising candidate treatment.•Nanoparticles combined with chemotherapy, are more efficient compared to the antibody-drug conjugates alone.•Biomarkers are regarded as proper prognostic and predictive factors in breast cancer. During the past recent years, various therapies emerged in the era of breast cancer. Breast cancer is a heterogeneous disease in which genetic and environmental factors are involved. Breast cancer stem cells (BCSCs) are the main player in the aggressiveness of different tumors and also, these cells are the main challenge in cancer treatment. Moreover, the major obstacle to achieve an effective treatment is resistance to therapies. There are various types of treatment for breast cancer (BC) patients. Therefore, in this review, we present the current treatments, novel approaches such as antibody-drug conjugation systems (ADCs), nanoparticles (albumin-, metal-, lipid-, polymer-, micelle-based nanoparticles), and BCSCs-based therapies. Furthermore, prognostic and predictive biomarkers will be discussed also biomarkers that have been applied by some tests such as Oncotype DX, Mamm αPrint, and uPA/PAI-1 are regarded as suitable prognostic and predictive factors in breast cancer.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Breast cancer: Biology, biomarkers, and treatments

Barzaman, Khadijeh ; Karami, Jafar ; Zarei, Zeinab ; Hosseinzadeh, Aysooda ; Kazemi, Mohammad Hossein ; Moradi-Kalbolandi, Shima ; Safari, Elahe ; Farahmand, Leila

Netherlands: Elsevier B.V

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