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Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats

Dungar, Benjamin M ; Schupbach, Chad D ; Jacobson, Jessie R ; Kopf, Phillip G

Endocrinology (Philadelphia), 2021-11, Vol.162 (11), p.1 [Revista revisada por pares]

United States: Oxford University Press

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Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats
Autor: Dungar, Benjamin M ; Schupbach, Chad D ; Jacobson, Jessie R ; Kopf, Phillip G
Materias: Adrenal Cortex - cytology ; Adrenal Cortex - drug effects ; Adrenal Cortex - metabolism ; Adrenal Cortex Hormones - biosynthesis ; Aldosterone ; Animals ; Cardiovascular diseases ; Cardiovascular system ; Cell Line ; Cell Survival - drug effects ; Cell viability ; Corticosteroids ; Corticosterone ; Cortisol ; Endocrine disruptors ; Endocrine Disruptors - pharmacology ; Endocrinology ; Enzymes ; Epidemiology ; Ethers ; Ethylenediaminetetraacetic acid ; Exposure ; Gene expression ; Genes ; Halogenated Diphenyl Ethers - pharmacology ; Homeostasis ; Hormones ; Humans ; Kidneys ; Male ; Males ; Metabolic Networks and Pathways - drug effects ; Metabolism ; Molecular modelling ; Polybrominated diphenyl ethers ; Rats ; Rats, Sprague-Dawley ; Secretion ; Steroids ; Synthesis
Es parte de: Endocrinology (Philadelphia), 2021-11, Vol.162 (11), p.1
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SourceType-Scholarly Journals-1
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Descripción: Polybrominated diphenyl ethers (PBDEs) have been previously shown to alter various endocrine biosynthetic pathways. Growing epidemiological evidence suggests that PBDEs alter cardiovascular function. The goal of this study was to examine the effects of BDE-47 on adrenal corticosteroid pathways that play vital roles in cardiovascular homeostasis and pathophysiology. The effect of BDE-47 on aldosterone and cortisol secretion was characterized in a human adrenocortical cell line. HAC15 cells were exposed to various concentrations of BDE-47 (1 nM to 100 μM). Cell viability, corticosteroid secretion, gene expression of enzymes involved in corticosteroid synthesis, and metabolic activity was examined. Additionally, Sprague Dawley male rats were orally exposed to BDE-47 (10 or 100 µg/kg), 5 days per week for 16 weeks. Organ weights and plasma corticosteroid levels were measured. In HAC15 cells, basal and stimulated aldosterone and cortisol secretion was significantly increased by BDE-47. Gene expression of several enzymes involved in corticosteroid synthesis and mitochondrial metabolism also increased. In Sprague Dawley rats, adrenal but not heart, kidney, or liver weights, were significantly increased in BDE-47 treatment groups. Plasma corticosterone levels were significantly increased in the 100 µg BDE-47/kg treatment group. No change in plasma aldosterone levels were observed with BDE-47 exposure. These data indicate that BDE-47 disrupts the regulation of corticosteroid secretion and provides further evidence that PBDEs are potential endocrine disruptors. Future studies will determine the underlying molecular mechanism of altered corticosteroid production and examine whether these alterations result in underlying cardiovascular disease in our rodent model of 16-week BDE-47 exposure.
Editor: United States: Oxford University Press
Idioma: Inglés

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Adrenal Corticosteroid Perturbation by the Endocrine Disruptor BDE-47 in a Human Adrenocortical Cell Line and Male Rats

Dungar, Benjamin M ; Schupbach, Chad D ; Jacobson, Jessie R ; Kopf, Phillip G

United States: Oxford University Press

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