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Circulating Antibody-Secreting Cells during Acute Respiratory Syncytial Virus Infection in Adults

Eun-Hyung Lee, F. ; Falsey, Ann R. ; Halliley, Jessica L. ; Sanz, Iñaki ; Walsh, Edward E.

The Journal of infectious diseases, 2010-12, Vol.202 (11), p.1659-1666 [Periódico revisado por pares]

Oxford: The University of Chicago Press

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Título:
Circulating Antibody-Secreting Cells during Acute Respiratory Syncytial Virus Infection in Adults
Autor: Eun-Hyung Lee, F. ; Falsey, Ann R. ; Halliley, Jessica L. ; Sanz, Iñaki ; Walsh, Edward E.
Assuntos: Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral - blood ; Antibody-Producing Cells - immunology ; Antigens, Viral ; B lymphocytes ; Biological and medical sciences ; Blood ; Diseases ; Enzyme-Linked Immunospot Assay ; Female ; Fundamental and applied biological sciences. Psychology ; Human respiratory syncytial virus ; Humans ; Infections ; Infectious diseases ; Major and Brief Reports ; Male ; Medical sciences ; Microbiology ; Middle Aged ; New York ; Orthomyxoviridae ; Prospective Studies ; Respiratory syncytial virus ; Respiratory syncytial virus infections ; Respiratory Syncytial Virus Infections - blood ; Respiratory Syncytial Virus Infections - diagnosis ; Respiratory Syncytial Virus Infections - immunology ; Respiratory syncytial viruses ; Respiratory Syncytial Viruses - genetics ; Respiratory Syncytial Viruses - immunology ; Respiratory Syncytial Viruses - isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction ; Viruses
É parte de: The Journal of infectious diseases, 2010-12, Vol.202 (11), p.1659-1666
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Descrição: Background. The specificity and duration of circulating human antibody-secreting cells (ASCs) after vaccination have been well described, but characteristics of ASCs during acute respiratory infections have not been well studied. Methods. Circulating antigen-specific ASCs were measured at 3 time points (enrollment, days 10–16, and days 22–45) in 40 adults during respiratory syncytial virus (RSV) infection. Results. Of the 40 patients, 36 (90%) had detectable circulating RSV F protein-specific ASCs within 11 days after illness onset. The magnitude of the RSV-specific ASCs was 1–1500 spots per 10 6peripheral blood mononuclear cells (mean frequency [± standard deviation], 200 ± 256 spots per 106 peripheral blood mononuclear cells). ASCs were detected on day 8–16 and day 22–45 after symptom onset in 78% and 48% of subjects, respectively. Subjects shedding virus for >10 days were more likely to have a positive response to ASC enzyme-linked immunospot assay at the late time point than those shedding for ⩽10 days (8 of 12 subjects vs 2 of 11 subjects; P = .02). Conclusions. The kinetics of ASC circulation during acute mucosal viral infections was more prolonged than that we had observed after a single intramuscular injection with inactivated influenza vaccine in a study reported elsewhere. The association between the duration of virus shedding and the persistence of detectable viral-specific ASCs suggests that ongoing antigen persistence induces a prolonged temporal pattern of ASC generation.
Editor: Oxford: The University of Chicago Press
Idioma: Inglês

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Circulating Antibody-Secreting Cells during Acute Respiratory Syncytial Virus Infection in Adults

Eun-Hyung Lee, F. ; Falsey, Ann R. ; Halliley, Jessica L. ; Sanz, Iñaki ; Walsh, Edward E.

Oxford: The University of Chicago Press

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