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Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection

Vriend, Henrike J ; Bogaards, Johannes A ; van der Klis, Fiona R M ; Scherpenisse, Mirte ; Boot, Hein J ; King, Audrey J ; van der Sande, Marianne A B Khudyakov, Yury E.

PloS one, 2013-04, Vol.8 (4), p.e60696 [Periódico revisado por pares]

United States: Public Library of Science

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Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection
Autor: Vriend, Henrike J ; Bogaards, Johannes A ; van der Klis, Fiona R M ; Scherpenisse, Mirte ; Boot, Hein J ; King, Audrey J ; van der Sande, Marianne A B
Khudyakov, Yury E.
Assuntos: Adolescent ; Anal Canal - virology ; Analysis ; Antibodies ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Antibody Specificity ; Biology ; Cancer ; Carcinogens ; Child ; Chlamydia ; Clinics ; Deoxyribonucleic acid ; Disease control ; DNA ; DNA, Viral - blood ; DNA, Viral - genetics ; Epidemiology ; Female ; Females ; Gender ; Genitalia, Female - virology ; Genitalia, Male - virology ; Genotype ; Gonorrhea ; Health aspects ; Heterosexuality ; Homology ; Homosexuality, Male ; Human papillomavirus ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - immunology ; Human papillomavirus 16 - isolation & purification ; Human papillomavirus 16 - physiology ; Human papillomavirus 18 - genetics ; Human papillomavirus 18 - immunology ; Human papillomavirus 18 - isolation & purification ; Human papillomavirus 18 - physiology ; Humans ; Infections ; Infectious diseases ; Male ; Males ; Mathematical models ; Medical research ; Medicine ; Medicine, Experimental ; Men ; Mens health ; Organ Specificity ; Papillomavirus ; Papillomavirus infections ; Papillomavirus Infections - blood ; Papillomavirus Infections - virology ; Papillomaviruses ; Population ; Public health ; Questionnaires ; Regression analysis ; Risk analysis ; Risk factors ; Risk taking ; Sexual behavior ; Sexually transmitted diseases ; STD ; Vaccines ; Viral antibodies ; Womens health ; Young Adult ; Young adults
É parte de: PloS one, 2013-04, Vol.8 (4), p.e60696
Notas: Deceased.
Competing Interests: The authors have declared that no competing interests exist.
Data collection: HV. Contributed to the serum antibody detection methods: FVDK MS. Contributed to the DNA detection methods: HB AK. Conceived and designed the experiments: MVDS HV HB FVDK. Analyzed the data: HV JB. Wrote the paper: HV JB FVDK MS HB AK MVDS.
Membership of the Medical Microbiological Laboratories and Municipal Health Services is provided in the Acknowledgments.
Descrição: To monitor the impact of human papillomavirus types 16 and 18 vaccine on HPV infection dynamics in the Netherlands, we started an ongoing study in sexually transmitted infection (STI) clinics in 2009. Here, we analyze baseline type-specific HPV DNA and HPV-specific antibody positivity rates. We enrolled 3569 men and women, 16-24 years of age, from 14 STI clinics, and estimated genital and anal HPV DNA and antibody positivity rates of 7 main carcinogenic HPV types. Generalized estimating equations regression analyses were applied to determine risk factors for, and associations between, type-specific HPV DNA and antibody positivity. Genital HPV DNA positivity rates were higher in women than in men; anal HPV DNA was especially high in men who have sex with men (MSM). HPV antibody seropositivity rates were also highest in women and MSM. High-risk sexual behavior was predictive of both HPV DNA and antibody positivity. Despite a strong correlation in serological profiles for multiple HPV types, seropositivity was independently associated with homologous HPV DNA detection. HPV DNA and antibody positivity rates are higher in women and MSM than in heterosexual men, but their association is similar across gender. This suggests a site-specific natural course of infection.
Editor: United States: Public Library of Science
Idioma: Inglês

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Patterns of human papillomavirus DNA and antibody positivity in young males and females, suggesting a site-specific natural course of infection

Vriend, Henrike J ; Bogaards, Johannes A ; van der Klis, Fiona R M ; Scherpenisse, Mirte ; Boot, Hein J ; King, Audrey J ; van der Sande, Marianne A B Khudyakov, Yury E.

United States: Public Library of Science

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