Idioma:

De Novo Tumors Are a Major Cause of Late Mortality After Orthotopic Liver Transplantation

Baccarani, U ; Adani, G.L ; Serraino, D ; Lorenzin, D ; Gambato, M ; Buda, A ; Zanus, G ; Vitale, A ; Piselli, P ; De Paoli, A ; Bresadola, V ; Risaliti, A ; Toniutto, P ; Cillo, U ; Bresadola, F ; Burra, P

Transplantation proceedings, 2009-05, Vol.41 (4), p.1303-1305 [Periódico revisado por pares]

Amsterdam: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
De Novo Tumors Are a Major Cause of Late Mortality After Orthotopic Liver Transplantation
Autor: Baccarani, U ; Adani, G.L ; Serraino, D ; Lorenzin, D ; Gambato, M ; Buda, A ; Zanus, G ; Vitale, A ; Piselli, P ; De Paoli, A ; Bresadola, V ; Risaliti, A ; Toniutto, P ; Cillo, U ; Bresadola, F ; Burra, P
Assuntos: Biological and medical sciences ; Epidemiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Humans ; Liver Transplantation ; Liver, biliary tract, pancreas, portal circulation, spleen ; Medical sciences ; Neoplasms - etiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the digestive system ; Survival Rate ; Tissue, organ and graft immunology
É parte de: Transplantation proceedings, 2009-05, Vol.41 (4), p.1303-1305
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract The purpose of this study was to describe de novo post–orthotopic liver transplantation (OLT) malignancies for comparison with incidence rates in Italian cancer registries. Three hundred thirteen OLT patients engrafted from 1991 to 2006 and surviving 12 months without a previous diagnosis of cancer were evaluated for the development of de novo malignancies excluding nonmelanoma skin cancers. During a total follow-up time of 1753 PYs, 40 (12.8%) de novo malignancies were diagnosed in 40 recipients. The most common cancers were non-Hodgkin lymphoma (NHL; 20%), cancer of the head and neck (17%), Kaposi sarcoma (KS; 17%), and esophageal tumors (12%). The 1-, 3-, 5-, and 10-year estimated survival rates were 70%, 56%, 48%, and 39%. Patients with de novo cancers showed a lower 10-years survival rate ( P = .0047) than patients without (39% vs 75%). The risk of cancer after OLT was 3-fold higher than that of the general population of the same age and gender (95% confidence interval [CI], 2.0–4.3). De novo tumor sites or types with significantly elevated standardized incidence ratios (SIRs) included KS (SIRs = 212), NHL (SIRs = 13.7), oesophagus (SIRs = 18.7), melanoma (SIRs = 10.1), and head and neck cancers (SIRs = 4.6). Tumors after OLT were associated with lower long-term survival, confirming that cancer is a major cause of late mortality.
Editor: Amsterdam: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

De Novo Tumors Are a Major Cause of Late Mortality After Orthotopic Liver Transplantation

Baccarani, U ; Adani, G.L ; Serraino, D ; Lorenzin, D ; Gambato, M ; Buda, A ; Zanus, G ; Vitale, A ; Piselli, P ; De Paoli, A ; Bresadola, V ; Risaliti, A ; Toniutto, P ; Cillo, U ; Bresadola, F ; Burra, P

Amsterdam: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.