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High Level of Lipoprotein(a) as Predictor for Recurrent Heart Failure in Patients with Chronic Heart Failure: a Cohort Study

Yan, Jianlong ; Pan, Yanbin ; Xiao, Junhui ; Ma, Wenxue ; Li, Li ; Zhong, Mingjiang ; Long, Haiquan ; Kong, Fanliang ; Shao, Wenming

Arquivos brasileiros de cardiologia, 2019-08, Vol.113 (2), p.197-204 [Periódico revisado por pares]

Brazil: Sociedade Brasileira de Cardiologia - SBC

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Título:
High Level of Lipoprotein(a) as Predictor for Recurrent Heart Failure in Patients with Chronic Heart Failure: a Cohort Study
Autor: Yan, Jianlong ; Pan, Yanbin ; Xiao, Junhui ; Ma, Wenxue ; Li, Li ; Zhong, Mingjiang ; Long, Haiquan ; Kong, Fanliang ; Shao, Wenming
Assuntos: Aged ; Aged, 80 and over ; Apolipoproteins ; CARDIAC & CARDIOVASCULAR SYSTEMS ; Chronic Disease ; Cohort Studies ; Coronary Artery Disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Diabetes Mellitus ; Echocardiography ; Echocardiography/methods ; Female ; Heart Failure ; Heart Failure - blood ; Heart Failure - etiology ; Humans ; Hypertension ; Kaplan-Meier Estimate ; Lipoprotein(a) - blood ; Lipoproteins ; Male ; Middle Aged ; Original ; Recurrence ; Reference Values ; Regression Analysis ; Retrospective Studies ; Risk Assessment - methods ; Risk Factors ; Statistics, Nonparametric ; Time Factors
É parte de: Arquivos brasileiros de cardiologia, 2019-08, Vol.113 (2), p.197-204
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
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Descrição: Elevated plasma levels of Lipoprotein(a) [Lp(a)] are recognized as a significant risk factor for atherosclerotic vascular disease. However, there are limited data regarding association between Lp(a) and recurrent heart failure (HF) in patients with chronic HF caused by coronary heart disease (CHD). Elevated levels of Lp(a) might have a prognostic impact on recurrent HF in patients with chronic HF caused by CHD. A total of 309 patients with chronic HF caused by CHD were consecutively enrolled in this study. The patients were divided into 2 groups according to whether Lp(a) levels were above or below the median level for the entire cohort (20.6 mg/dL): the high Lp(a) group (n = 155) and the low Lp(a) group (n = 154). A 2-sided p < 0.05 was statistically considered significant. During the median follow-up period of 186 days, 31 cases out of a total of 309 patients (10.03%) could not be reached during follow-up. A Kaplan-Meier analysis demonstrated that patients with higher Lp(a) levels had a higher incidence of recurrent HF than those with lower Lp(a) levels (log-rank < 0.0001). A multivariate Cox regression analysis revealed that Lp(a) levels were independently correlated with the incidence of recurrent HF after adjustment of potential confounders (hazard ratio: 2.720, 95 % confidence interval: 1.730-4.277, p < 0.0001). In Chinese patients with chronic HF caused by CHD, elevated levels of Lp(a) are independently associated with recurrent HF.
Editor: Brazil: Sociedade Brasileira de Cardiologia - SBC
Idioma: Inglês;Português

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High Level of Lipoprotein(a) as Predictor for Recurrent Heart Failure in Patients with Chronic Heart Failure: a Cohort Study

Yan, Jianlong ; Pan, Yanbin ; Xiao, Junhui ; Ma, Wenxue ; Li, Li ; Zhong, Mingjiang ; Long, Haiquan ; Kong, Fanliang ; Shao, Wenming

Brazil: Sociedade Brasileira de Cardiologia - SBC

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