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Sequence and Evolution of HLA-DR7- and -DRw53-Associated β -Chain Genes

John A. T. Young ; Wilkinson, David ; Bodmer, Walter F. ; Trowsdale, John

Proc. Natl. Acad. Sci. U.S.A.; (United States), 1987-07, Vol.84 (14), p.4929-4933 [Periódico revisado por pares]

Washington, DC: National Academy of Sciences of the United States of America

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Título:
Sequence and Evolution of HLA-DR7- and -DRw53-Associated β -Chain Genes
Autor: John A. T. Young ; Wilkinson, David ; Bodmer, Walter F. ; Trowsdale, John
Assuntos: 550200 - Biochemistry ; Alleles ; Amino Acid Sequence ; Amino acids ; ANIMAL CELLS ; ANIMALS ; Antibodies ; ANTIGENS ; B-Lymphocytes - analysis ; Base Sequence ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EVOLUTION ; CARBOHYDRATES ; CELL FLOW SYSTEMS ; Cell Line ; Cell lines ; Complementary DNA ; DNA ; DNA - genetics ; DNA SEQUENCING ; Fundamental and applied biological sciences. Psychology ; Gene Conversion ; Genes ; Genes, MHC Class II ; Genes. Genome ; Genetic loci ; GLUCOPROTEINS ; Haplotypes ; HLA-D Antigens - genetics ; HLA-DR Antigens - genetics ; HLA-DR7 Antigen ; HLA-DRB4 Chains ; Humans ; L cells ; L Cells (Cell Line) ; MAMMALS ; MAN ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecules ; Monoclonal antibodies ; NUCLEIC ACIDS ; ORGANIC COMPOUNDS ; Polymorphism, Genetic ; PRIMATES ; PROTEINS ; RECOMBINANT DNA ; SACCHARIDES ; STRUCTURAL CHEMICAL ANALYSIS ; TUMOR CELLS ; VERTEBRATES
É parte de: Proc. Natl. Acad. Sci. U.S.A.; (United States), 1987-07, Vol.84 (14), p.4929-4933
Notas: ObjectType-Article-2
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Descrição: cDNA clones representing products of the DR7 and DRw53 β -chain genes were isolated from the human B-lymphoblastoid cell line MANN (DR7,DRw53,DQw2,DPw2). The DRw53β sequence was identical to a DRw53β sequence derived from cells with a DR4 haplotype. In contrast, the DR7β sequence was as unrelated to DR4β sequence as it was to other DRβ -related genes, except at the 3′-untranslated region. These results suggest that the DR7 and DR4 haplotypes may have been derived relatively recently from a common ancestral haplotype and that the DR4 and DR7 β -chain genes have undergone more rapid diversification in their β 1 domains, most probably as a result of natural selection, than have the DRw53 β -chain genes. Short tracts of sequence within the DR7 and DRw53 β 1 domains were shared with other DRβ sequences, indicating that exchanges of genetic information between β 1 domains of DRβ -related genes have played a part in their evolution. Serological analysis of mouse L-cell transfectants expressing surface HLA-DR7 molecules, confirmed by antibody binding and allelic sequence comparisons, identified amino acid residues that may be critical to the binding of a monomorphic DR- and DP-specific monoclonal antibody.
Editor: Washington, DC: National Academy of Sciences of the United States of America
Idioma: Inglês

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Sequence and Evolution of HLA-DR7- and -DRw53-Associated β -Chain Genes

John A. T. Young ; Wilkinson, David ; Bodmer, Walter F. ; Trowsdale, John

Washington, DC: National Academy of Sciences of the United States of America

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