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Sol-gel Silica Nanoparticles in Medicine: A Natural Choice. Design, Synthesis and Products

Gonçalves, M Clara

Molecules (Basel, Switzerland), 2018-08, Vol.23 (8), p.2021 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Sol-gel Silica Nanoparticles in Medicine: A Natural Choice. Design, Synthesis and Products
Autor: Gonçalves, M Clara
Assuntos: Biocompatibility ; biogeochemical cycle ; Biomaterials ; Biomedical materials ; Biomimetics ; Blood circulation ; Colloiding ; Dentistry ; Dermatology ; Drug delivery systems ; Food chains ; Functional groups ; Homogeneity ; LaMer ; Minerals ; Nanoparticles ; Organic chemistry ; Orthopedics ; Pollutants ; Production methods ; reverse emulsion ; Review ; Silica ; Silica gel ; Silicon dioxide ; sol-gel ; Sol-gel processes ; Stöber ; Surfactants ; Target recognition
É parte de: Molecules (Basel, Switzerland), 2018-08, Vol.23 (8), p.2021
Descrição: Silica is one of the most abundant minerals in the Earth's crust, and over time it has been introduced first into human life and later into engineering. Silica is present in the food chain and in the human body. As a biomaterial, silica is widely used in dentistry, orthopedics, and dermatology. Recently amorphous sol-gel SiO₂ nanoparticles (NPs) have appeared as nanocarriers in a wide range of medical applications, namely in drug/gene target and imaging , where they stand out for their high biocompatibility, hydrophilicity, enormous flexibility for surface modification with a high payload capacity, and prolonged blood circulation time. The sol-gel process is an extremely versatile methodology used in the synthesis of silica NPs, offering a great variety of chemical possibilities, such as high homogeneity and purity, along with full scale pH processing. By introducing organic functional groups or surfactants during the sol-gel process, NPs or mesoporous NPs are produced. Colloidal route, biomimetic synthesis, solution route and template synthesis (the main sol-gel methods to produce monosized silica nanoparticles) are compared and discussed. This short review goes over some of the emerging approaches in the field of non-porous sol-gel silica NPs aiming at medical applications, centered on the syntheses processes used.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Sol-gel Silica Nanoparticles in Medicine: A Natural Choice. Design, Synthesis and Products

Gonçalves, M Clara

Switzerland: MDPI AG

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