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Human immunodeficiency virus transmission-Mechanisms underlying the cell-to-cell spread of human immunodeficiency virus

Calado, Marta ; Pires, David ; Conceição, Carolina ; Santos-Costa, Quirina ; Anes, Elsa ; Azevedo-Pereira, José Miguel

Reviews in medical virology, 2023-11, Vol.33 (6), p.e2480-e2480 [Periódico revisado por pares]

England: Wiley Periodicals Inc

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  • Título:
    Human immunodeficiency virus transmission-Mechanisms underlying the cell-to-cell spread of human immunodeficiency virus
  • Autor: Calado, Marta ; Pires, David ; Conceição, Carolina ; Santos-Costa, Quirina ; Anes, Elsa ; Azevedo-Pereira, José Miguel
  • Assuntos: Antiretroviral therapy ; CD4 antigen ; CD4-Positive T-Lymphocytes ; Cell fusion ; Dendritic Cells ; Disease transmission ; Filopodia ; HIV ; HIV Infections ; HIV-1 - physiology ; Human immunodeficiency virus ; Humans ; Immune system ; Lymphocytes T ; Macrophages ; Nanotubes ; Sexual intercourse ; Viruses
  • É parte de: Reviews in medical virology, 2023-11, Vol.33 (6), p.e2480-e2480
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Despite the success of combined antiretroviral therapy in controlling viral load and reducing the risk of human immunodeficiency virus (HIV) transmission, an estimated 1.5 million new infections occurred worldwide in 2021. These new infections are mainly the result of sexual intercourse and thus involve cells present on the genital mucosa, such as dendritic cells (DCs), macrophages (Mø) and CD4+ T lymphocytes. Understanding the mechanisms by which HIV interacts with these cells and how HIV exploits these interactions to establish infection in a new human host is critical to the development of strategies to prevent and control HIV transmission. In this review, we explore how HIV has evolved to manipulate some of the physiological roles of these cells, thereby gaining access to strategic cellular niches that are critical for the spread and pathogenesis of HIV infection. The interaction of HIV with DCs, Mø and CD4+ T lymphocytes, and the role of the intercellular transfer of viral particles through the establishment of the infectious or virological synapses, but also through membrane protrusions such as filopodia and tunnelling nanotubes (TNTs), and cell fusion or cell engulfment processes are presented and discussed.
  • Editor: England: Wiley Periodicals Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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