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Cause-Specific Life Expectancies After 35 Years of Age for Human Immunodeficiency Syndrome-Infected and Human Immunodeficiency Syndrome-Negative Individuals Followed Simultaneously in Long-term Cohort Studies, 1984―2008

WADA, Nikolas ; JACOBSON, Lisa P ; COHEN, Mardge ; FRENCH, Audrey ; PHAIR, John ; MUNOZ, Alvaro

American journal of epidemiology, 2013-01, Vol.177 (2), p.116-125 [Periódico revisado por pares]

Cary, NC: Oxford University Press

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Título:
Cause-Specific Life Expectancies After 35 Years of Age for Human Immunodeficiency Syndrome-Infected and Human Immunodeficiency Syndrome-Negative Individuals Followed Simultaneously in Long-term Cohort Studies, 1984―2008
Autor: WADA, Nikolas ; JACOBSON, Lisa P ; COHEN, Mardge ; FRENCH, Audrey ; PHAIR, John ; MUNOZ, Alvaro
Assuntos: Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - mortality ; Adult ; Age Factors ; Aged ; AIDS ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; Case-Control Studies ; Cause of Death ; Cohort Studies ; Epidemiology ; Female ; General aspects ; HIV ; HIV Infections - drug therapy ; HIV Infections - mortality ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infectious diseases ; Life Expectancy ; Longitudinal Studies ; Male ; Medical research ; Medical sciences ; Middle Aged ; Miscellaneous ; Models, Statistical ; Mortality ; Multivariate Analysis ; Practice of Epidemiology ; Proportional Hazards Models ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; United States - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
É parte de: American journal of epidemiology, 2013-01, Vol.177 (2), p.116-125
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Abbreviations: AIDS, acquired immune deficiency syndrome; HAART, highly active antiretroviral therapy; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, human immunodeficiency virus; , estimated hazard ratio; IDU, injection drug use; MACS, Multicenter AIDS Cohort Study; WIHS, Women's Interagency HIV Study.
Descrição: Parametric and semiparametric competing risks methods were used to estimate proportions, timing, and predictors of acquired immune deficiency syndrome (AIDS)-related and non-AIDS-related mortality among individuals both positive and negative for the human immunodeficiency syndrome (HIV) in the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) from 1984 to 2008 and 1996 to 2008, respectively. Among HIV-positive MACS participants, the proportion of deaths unrelated to AIDS increased from 6% before the introduction of highly active antiretroviral therapy (HAART) (before 1996) to 53% in the HAART era (P < 0.01); the median age of persons who died from non-AIDS-related causes after age 35 years increased from 49.0 to 66.0 years (P < 0.01). In both cohorts during the HAART era, median ages at time of non-AIDS-related death were younger for HIV-positive individuals than for comparable HIV-negative individuals (8.7 years younger in MACS (P < 0.01) and 7.6 years younger in WIHS (P < 0.01)). In a multivariate proportional cause-specific hazards model, unemployment (for non-AIDS death, hazard ratio (HR) = 1.8; for AIDS death, HR = 2.3), depression (for non-AIDS death, HR = 1.4; for AIDS death, HR = 1.4), and hepatitis B or C infection (for non-AIDS death, HR = 1.8, for AIDS death; HR = 1.4) were significantly (P < 0.05) associated with higher hazards of both non-AIDS and AIDS mortality among HIV-positive individuals in the HAART era, independent of study cohort. The results illuminate the changing face of mortality among the growing population infected with HIV.
Editor: Cary, NC: Oxford University Press
Idioma: Inglês

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Cause-Specific Life Expectancies After 35 Years of Age for Human Immunodeficiency Syndrome-Infected and Human Immunodeficiency Syndrome-Negative Individuals Followed Simultaneously in Long-term Cohort Studies, 1984―2008

WADA, Nikolas ; JACOBSON, Lisa P ; COHEN, Mardge ; FRENCH, Audrey ; PHAIR, John ; MUNOZ, Alvaro

Cary, NC: Oxford University Press

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