Idioma:

CRP in Outpatients with Inflammatory Bowel Disease Is Linked to the Blood Microbiota

Xu, Jie ; Molin, Göran ; Davidson, Sanna ; Roth, Bodil ; Sjöberg, Klas ; Håkansson, Åsa

International journal of molecular sciences, 2023-06, Vol.24 (13), p.10899 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por

Enviar para

Título:
CRP in Outpatients with Inflammatory Bowel Disease Is Linked to the Blood Microbiota
Autor: Xu, Jie ; Molin, Göran ; Davidson, Sanna ; Roth, Bodil ; Sjöberg, Klas ; Håkansson, Åsa
Assuntos: Achromobacter ; Analysis ; Bacteria ; Biological diversity ; Biomarkers ; Biomedical Laboratory Science/Technology ; Biomedicinsk laboratorievetenskap/teknologi ; blood ; Blood & organ donations ; Blood circulation ; C-Reactive Protein ; Clinical Medicine ; Colitis, Ulcerative - microbiology ; Contamination ; Crohn Disease - microbiology ; Crohn's disease ; CRP ; Cystic fibrosis ; Development and progression ; Disease ; Disinfection & disinfectants ; diversity ; Gastroenterologi ; Gastroenterology and Hepatology ; Health aspects ; Health care ; Humans ; IBD ; Infections ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - microbiology ; Intestine ; Klinisk medicin ; Laboratories ; Medical and Health Sciences ; Medical Biotechnology ; Medicin och hälsovetenskap ; Medicinsk bioteknologi ; Metagenomics ; Microbiota ; Microbiota (Symbiotic organisms) ; Microorganisms ; Outpatients ; Pathogens ; Patients ; Phenotypes ; Public health ; Reagents ; Remission (Medicine) ; Taxonomy ; Therapeutic applications ; Ulcerative colitis ; Womens health
É parte de: International journal of molecular sciences, 2023-06, Vol.24 (13), p.10899
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
Descrição: The circulation is a closed system that has been assumed to be free from bacteria, but evidence for the existence of a low-density blood microbiota is accumulating. The present study aimed to map the blood microbiota of outpatients with Crohn's disease (CD) or with ulcerative colitis (UC) by 16S metagenomics. A diverse microbiota was observed in the blood samples. Regardless of the type of disease, the alpha diversity of the microbiota was positively associated with C-reactive protein (CRP). The blood microbiota had a surprisingly high proportion of in comparison with human oral and colonic microbiotas. There was no clear difference in the overall pattern of the microbiota between CD and UC. A non-template control (NTC) was included in the whole process to control for the potential contamination from the environment and reagents. Certain bacterial taxa were concomitantly detected in both blood samples and NTC. However, , , and were found in blood from both CD and UC patients but not in NTC, indicating the existence of a specific blood-borne microbiota in the patients. dominated in all blood samples, but a minor amount was also found in NTC. was significantly enriched in CD, but it was also detected in high abundance in NTC. Whether the composition of the blood microbiota could be a marker of a particular phenotype in inflammatory bowel disease (IBD) or whether the blood microbiota could be used for diagnostic or therapeutic purposes deserves further attention.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

CRP in Outpatients with Inflammatory Bowel Disease Is Linked to the Blood Microbiota

Xu, Jie ; Molin, Göran ; Davidson, Sanna ; Roth, Bodil ; Sjöberg, Klas ; Håkansson, Åsa

Switzerland: MDPI AG

Buscando em bases de dados remotas. Favor aguardar.