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In Vitro Anti-Inflammatory and Skin Protective Effects of Codium fragile Extract on Macrophages and Human Keratinocytes in Atopic Dermatitis

A-yeong Jang ; Jeongun Choi ; Weerawan Rod-in ; Ki Young Choi ; Dae-hee Lee ; Woo Jung Park

Journal of microbiology and biotechnology, 2024-04, Vol.34 (4), p.940 [Periódico revisado por pares]

한국미생물생명공학회

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  • Título:
    In Vitro Anti-Inflammatory and Skin Protective Effects of Codium fragile Extract on Macrophages and Human Keratinocytes in Atopic Dermatitis
  • Autor: A-yeong Jang ; Jeongun Choi ; Weerawan Rod-in ; Ki Young Choi ; Dae-hee Lee ; Woo Jung Park
  • Assuntos: atopic dermatitis ; barrier function ; Codium fragile ; inflammation
  • É parte de: Journal of microbiology and biotechnology, 2024-04, Vol.34 (4), p.940
  • Notas: The Korean Society for Applied Microbiology
  • Descrição: Codium fragile has been traditionally used in oriental medicine to treat enterobiasis, dropsy, and dysuria, and it has been shown to possess many biological properties. Atopic dermatitis (AD) is one of the types of skin inflammation and barrier disruption, which leads to chronic inflammatory skin diseases. In the current investigation, the protective effects of C. fragile extract (CFE) on antiinflammation and skin barrier improvement were investigated. In LPS-stimulated RAW 264.7 cells, nitric oxide generation and the expression levels of interleukin (IL)-1β, IL-4, IL-6, iNOS, COX-2, and tumor necrosis factor-alpha (TNF)-α were reduced by CFE. CFE also inhibited the phosphorylation of NF-κB-p65, ERK, p-38, and JNK. Additionally, CFE showed inhibitory activity on TSLP and IL-4 expression in HaCaT cells stimulated with TNF-α/interferon- gamma (IFN-γ). Enhanced expression of factors related to skin barrier function, FLG, IVL, and LOR, was confirmed. These findings implied that CFE may be used as a therapeutic agent against AD due to its skin barrier-strengthening and anti-inflammatory activities, which are derived from natural marine products.
  • Editor: 한국미생물생명공학회
  • Idioma: Coreano
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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