Idioma:

Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy

MARTIN, Michael B. ; GRIMLEY, Joshua S. ; LEWIS, Jared C. ; HEATH, Huel T. ; BAILEY, Brian N. ; KENDRICK, Howard ; YARDLEY, Vanessa ; CALDERA, Aura ; LIRA, Renee ; URBINA, Julio A. ; MORENO, Silvia N. J. ; DOCAMPO, Roberto ; CROFT, Simon L. ; OLDFIELD, Eric

Journal of medicinal chemistry, 2001-03, Vol.44 (6), p.909-916 [Periódico revisado por pares]

Washington, DC: American Chemical Society

Texto completo disponível

Citações Citado por

Enviar para

Título:
Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy
Autor: MARTIN, Michael B. ; GRIMLEY, Joshua S. ; LEWIS, Jared C. ; HEATH, Huel T. ; BAILEY, Brian N. ; KENDRICK, Howard ; YARDLEY, Vanessa ; CALDERA, Aura ; LIRA, Renee ; URBINA, Julio A. ; MORENO, Silvia N. J. ; DOCAMPO, Roberto ; CROFT, Simon L. ; OLDFIELD, Eric
Assuntos: Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Antiprotozoal Agents - pharmacology ; Biological and medical sciences ; Cercopithecus aethiops ; Diphosphonates - pharmacology ; Leishmania donovani - drug effects ; Medical sciences ; Pharmacology. Drug treatments ; Plasmodium falciparum - drug effects ; Structure-Activity Relationship ; Toxoplasma - drug effects ; Trypanosoma brucei brucei - drug effects ; Trypanosoma cruzi - drug effects ; Vero Cells
É parte de: Journal of medicinal chemistry, 2001-03, Vol.44 (6), p.909-916
Notas: istex:BB48F161229D9A9932929FE1948A6DBE589AF41B
ark:/67375/TPS-SM8R1G5R-F
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: We have investigated the effects in vitro of a series of bisphosphonates on the proliferation of Trypanosoma cruzi, Trypanosoma brucei rhodesiense, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum. The results show that nitrogen-containing bisphosphonates of the type used in bone resorption therapy have significant activity against parasites, with the aromatic species having in some cases nanomolar or low-micromolar IC(50) activity values against parasite replication (e.g. o-risedronate, IC(50) = 220 nM for T. brucei rhodesiense; risedronate, IC(50) = 490 nM for T. gondii). In T. cruzi, the nitrogen-containing bisphosphonate risedronate is shown to inhibit sterol biosynthesis at a pre-squalene level, most likely by inhibiting farnesylpyrophosphate synthase. Bisphosphonates therefore appear to have potential in treating parasitic protozoan diseases.
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy

MARTIN, Michael B. ; GRIMLEY, Joshua S. ; LEWIS, Jared C. ; HEATH, Huel T. ; BAILEY, Brian N. ; KENDRICK, Howard ; YARDLEY, Vanessa ; CALDERA, Aura ; LIRA, Renee ; URBINA, Julio A. ; MORENO, Silvia N. J. ; DOCAMPO, Roberto ; CROFT, Simon L. ; OLDFIELD, Eric

Washington, DC: American Chemical Society

Buscando em bases de dados remotas. Favor aguardar.