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First generation leishmaniasis vaccines: A review of field efficacy trials

Noazin, Sassan ; Modabber, Farrokh ; Khamesipour, Ali ; Smith, Peter G ; Moulton, Lawrence H ; Nasseri, Kiumarss ; Sharifi, Iraj ; Khalil, Eltahir A.G ; Bernal, Ivan Dario Velez ; Antunes, Carlos M.F ; Kieny, Marie Paule ; Tanner, Marcel

Vaccine, 2008-12, Vol.26 (52), p.6759-6767 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

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Título:
First generation leishmaniasis vaccines: A review of field efficacy trials
Autor: Noazin, Sassan ; Modabber, Farrokh ; Khamesipour, Ali ; Smith, Peter G ; Moulton, Lawrence H ; Nasseri, Kiumarss ; Sharifi, Iraj ; Khalil, Eltahir A.G ; Bernal, Ivan Dario Velez ; Antunes, Carlos M.F ; Kieny, Marie Paule ; Tanner, Marcel
Assuntos: Africa - epidemiology ; Allergy and Immunology ; Animals ; Applied microbiology ; Asia - epidemiology ; Biological and medical sciences ; Clinical trial ; Clinical Trials as Topic ; Fundamental and applied biological sciences. Psychology ; Human protozoal diseases ; Humans ; Immunization ; Infectious diseases ; Leishmania - immunology ; Leishmaniasis ; Leishmaniasis - immunology ; Leishmaniasis - prevention & control ; Leishmaniasis Vaccines - therapeutic use ; Leshmaniasis ; Medical sciences ; Microbiology ; Parasites ; Parasitic diseases ; Protozoal diseases ; Randomized Controlled Trials as Topic ; Review ; South America - epidemiology ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
É parte de: Vaccine, 2008-12, Vol.26 (52), p.6759-6767
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Descrição: Abstract First generation candidate vaccines against leishmaniasis, prepared using inactivated whole parasites as their main ingredient, were considered as promising because of their relative ease of production and low cost. These vaccines have been the subject of many investigations over several decades and are the only leishmaniasis vaccine candidates which have undergone phase 3 clinical trial evaluation. Although the studies demonstrated the safety of the vaccines and several studies showed reasonable immunogenicity and some indication of protection, an efficacious prophylactic vaccine is yet to be identified. Despite this overall failure, these trials contributed significantly to increasing knowledge on human leishmaniasis immunology. To provide a collective view, this review discusses the methods and findings of field efficacy trials of first generation leishmaniasis vaccine clinical trials conducted in the Old and New Worlds.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

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First generation leishmaniasis vaccines: A review of field efficacy trials

Noazin, Sassan ; Modabber, Farrokh ; Khamesipour, Ali ; Smith, Peter G ; Moulton, Lawrence H ; Nasseri, Kiumarss ; Sharifi, Iraj ; Khalil, Eltahir A.G ; Bernal, Ivan Dario Velez ; Antunes, Carlos M.F ; Kieny, Marie Paule ; Tanner, Marcel

Kidlington: Elsevier Ltd

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