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A systematic scientometric review of paternal inheritance of acquired metabolic traits

Crisóstomo, Luís ; Oliveira, Pedro F ; Alves, Marco G

figshare 2023

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  • Título:
    A systematic scientometric review of paternal inheritance of acquired metabolic traits
  • Autor: Crisóstomo, Luís ; Oliveira, Pedro F ; Alves, Marco G
  • Assuntos: Epigenetics (incl. genome methylation and epigenomics) ; Medical biochemistry - amino acids and metabolites ; Medical biochemistry - carbohydrates ; Medical biochemistry - lipids ; Public health nutrition
  • Descrição: Publicly available data used to produce the manuscript "A systematic scientometric review of paternal inheritance of acquired metabolic traits". These include the scripts used for the initial Scopus bibliographical search and for extracting bibliographical information of selected publications, the spreadsheets with stepwise screening of the publications, the datasets used in the “Multiomics integration” section and the R script to process the multiomics datasets. Please find the abstract below:Background:The concept of the inheritance of acquired traits, a foundational principle of Lamarck's evolutionary theory, has garnered renewed attention in recent years. Evidence for this phenomenon remained limited for decades but gained prominence with the Överkalix cohort study in 2002. This study revealed a link between cardiovascular disease incidence and the food availability experienced by individuals' grandparents during their slow-growth periods, reigniting interest in the inheritance of acquired traits, particularly in the context of non-communicable diseases. This scientometric analysis and systematic review comprehensively explores the current landscape of paternally transmitted acquired metabolic traits.Results:Utilizing Scopus Advanced search and meticulous screening, we included mammalian studies that document the inheritance or modification of metabolic traits in subsequent generations of unexposed descendants. Our inclusive criteria encompass intergenerational and transgenerational studies, as well as multigenerational exposures. Predominantly, this field has been driven by a select group of researchers, potentially shaping the design and focus of existing studies. Consequently, the literature primarily comprises transgenerational rodent investigations into the effects of ancestral exposure to environmental pollutants on sperm DNA methylation. The complexity and volume of data often lead to multiple or redundant publications. This practice, while understandable, may obscure the true extent of the impact of ancestral exposures on the health of non-exposed descendants. In addition to DNA methylation, studies have illuminated the role of sperm RNAs and histone marks in paternally acquired metabolic disorders, expanding our understanding of the mechanisms underlying epigenetic inheritance.Conclusions:This review serves as a comprehensive resource, shedding light on the current state of research in this critical area of science, and underscores the need for continued exploration to uncover the full spectrum of paternally mediated metabolic inheritance.
  • Editor: figshare
  • Data de criação/publicação: 2023
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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