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Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir

Daisy Maria Machado Aída de Fátima Barbosa Gouvêa; Maria Regina Alves Cardoso; Suênia Vasconcelos Beltrão; Kelly Simone Cunegundes; Fabiana Bononi; Fernanda Almeida; Kaline Cavalheiro; Daniela Souza Araújo de Angelis; Regina Célia de Menezes Succi

Brazilian Journal of Infectious Diseases Salvador v. 11, n. 1, p. 16-19, 2007

Salvador 2007

Localização: FSP - Faculdade de Saúde Pública    (HEP-10/2008 )(Acessar)

  • Título:
    Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir
  • Autor: Daisy Maria Machado
  • Aída de Fátima Barbosa Gouvêa; Maria Regina Alves Cardoso; Suênia Vasconcelos Beltrão; Kelly Simone Cunegundes; Fabiana Bononi; Fernanda Almeida; Kaline Cavalheiro; Daniela Souza Araújo de Angelis; Regina Célia de Menezes Succi
  • Assuntos: EPITOPOS; HIV; GENES; RETROVIRIDAE (QUIMIOTERAPIA EFEITOS AVALIAÇÃO); IMUNOLOGIA CELULAR
  • É parte de: Brazilian Journal of Infectious Diseases Salvador v. 11, n. 1, p. 16-19, 2007
  • Descrição: Genetic analysis of HIV-1 is essential to improve treatment strategies and select epitopes for vaccine programs. The objective of this study was to determine whether known CD4+ and CD8+ epitopes were present in Brazilian HIV-1 strains. We used previously described CD8+ and CD4+ epitopes from the Los Alamos laboratory to search for these epitopes in the Brazilian sequences using the HIVbase program and we compared the frequency results with the analyses using physical-chemical profile tools from Network Protein Sequence Analysis (NPSA), and the SYFPEITHI program. Furthermore, this analysis was carried out with the Prosite tool using the GeneDoc program and ds/dn analyses using the Synonymous Nonsynonymous Analysis Program (SNAP). The HIVbase epitope mapping demonstrated that 30 CD8+ and 6 CD4+ epitopes were present in the Brazilian sequences at a high frequency. Only two of these epitopes were heavily glycosylated. Interestingly, ds/dn analyses showed evidence of purifying selective pressure. These types of analyses could be useful for the assessment of possible vaccine efficiency in populations
  • Editor: Salvador
  • Data de criação/publicação: 2007
  • Formato: p. 16-19.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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