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Whole-lung lavage for severe pulmonary alveolar proteinosis assisted by veno-venous extracorporeal membrane oxygenation: a case report

Moreira, João P ; Ferraz, Sofia ; Freitas, Cláudia ; Morais, António ; Albuquerque, Roberto R ; Fiuza, Carlos

Canadian journal of respiratory therapy : CJRT = Revue canadienne de la thérapie respiratoire : RCTR, 2019, Vol.55 (1), p.9-12 [Periódico revisado por pares]

Canada: The Canadian Society of Respiratory Therapists

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  • Título:
    Whole-lung lavage for severe pulmonary alveolar proteinosis assisted by veno-venous extracorporeal membrane oxygenation: a case report
  • Autor: Moreira, João P ; Ferraz, Sofia ; Freitas, Cláudia ; Morais, António ; Albuquerque, Roberto R ; Fiuza, Carlos
  • Assuntos: Case Report ; Case reports ; Extracorporeal membrane oxygenation ; Lung cancer ; Medical diagnosis ; Pharmacology ; Respiratory distress syndrome ; Respiratory failure
  • É parte de: Canadian journal of respiratory therapy : CJRT = Revue canadienne de la thérapie respiratoire : RCTR, 2019, Vol.55 (1), p.9-12
  • Descrição: Pulmonary alveolar proteinosis (PAP) is a rare pathology characterized by accumulation of phospholipoproteinaceous material within the alveoli. The evolution of PAP is variable and treatment modalities are limited. Pharmacological therapeutic targets are being actively developed, but whole-lung lavage (WLL), first described in the 1960s, remains the cornerstone of therapy. The preferential treatment for PAP in our center is sequential WLL, where each lung is separately and sequentially perfused with warmed saline. However, some patients do not tolerate single lung ventilation (SLV), as there is a greater risk of severe hypoxemia with this method. Extracorporeal membrane oxygenation (ECMO), referring to an extracorporeal circuit that directly oxygenates and removes carbon dioxide from the blood, may be considered in highly selected patients with severe respiratory failure who otherwise would not be able to undergo WLL. In this context, veno-venous ECMO is most often utilized. We describe a case of a 44-year-old male diagnosed with silicosis five years earlier who presented with severe hypoxemic respiratory failure not amenable to WLL under general anesthesia with SLV, which was successfully managed with ECMO-assisted WLL.
  • Editor: Canada: The Canadian Society of Respiratory Therapists
  • Idioma: Inglês
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