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Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

Ansari, Shamshul ; Yamaoka, Yoshio

International journal of molecular sciences, 2020-10, Vol.21 (19), p.7430 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity
Autor: Ansari, Shamshul ; Yamaoka, Yoshio
Assuntos: Amino acids ; Antigens, Bacterial - chemistry ; Antigens, Bacterial - genetics ; Antigens, Bacterial - metabolism ; Bacterial Proteins - chemistry ; Bacterial Proteins - genetics ; Bacterial Proteins - metabolism ; cag pathogenicity island ; CagA ; Cell proliferation ; Disease ; Epithelium ; Gastric cancer ; Gastric mucosa ; Gastric Mucosa - metabolism ; Gastric Mucosa - microbiology ; Genes ; H. pylori ; Health aspects ; Helicobacter Infections - genetics ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - pathogenicity ; Humans ; Infections ; Lymphoma ; Mucosal-associated lymphoid tissue ; Observations ; Pathogenicity ; Peptic Ulcer - metabolism ; Peptic Ulcer - microbiology ; Peptic ulcers ; Phosphorylation ; Proteins ; Review ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - microbiology ; Type IV Secretion Systems - genetics ; Tyrosine - metabolism ; Ulcers ; Virulence ; Virulence (Microbiology) ; Virulence - genetics ; virulence factor ; Virulence factors ; Virulence Factors - genetics
É parte de: International journal of molecular sciences, 2020-10, Vol.21 (19), p.7430
Descrição: causes persistent infection in the gastric epithelium of more than half of the world's population, leading to the development of severe complications such as peptic ulcer diseases, gastric cancer, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Several virulence factors, including cytotoxin-associated gene A (CagA), which is translocated into the gastric epithelium via the type 4 secretory system (T4SS), have been indicated to play a vital role in disease development. Although infection with strains harboring the East Asian type of CagA possessing the EPIYA-A, -B, and -D sequences has been found to potentiate cell proliferation and disease pathogenicity, the exact mechanism of CagA involvement in disease severity still remains to be elucidated. Therefore, we discuss the possible role of CagA in gastric pathogenicity.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Helicobacter pylori Virulence Factor Cytotoxin-Associated Gene A (CagA)-Mediated Gastric Pathogenicity

Ansari, Shamshul ; Yamaoka, Yoshio

Switzerland: MDPI AG

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