Idioma:

Brain structure and obesity

Raji, Cyrus A. ; Ho, April J. ; Parikshak, Neelroop N. ; Becker, James T. ; Lopez, Oscar L. ; Kuller, Lewis H. ; Hua, Xue ; Leow, Alex D. ; Toga, Arthur W. ; Thompson, Paul M.

Human brain mapping, 2010-03, Vol.31 (3), p.353-364 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Texto completo disponível

Citações Citado por

Enviar para

Título:
Brain structure and obesity
Autor: Raji, Cyrus A. ; Ho, April J. ; Parikshak, Neelroop N. ; Becker, James T. ; Lopez, Oscar L. ; Kuller, Lewis H. ; Hua, Xue ; Leow, Alex D. ; Toga, Arthur W. ; Thompson, Paul M.
Assuntos: Age Factors ; Aged ; Analysis of Variance ; Biological and medical sciences ; Body Mass Index ; Brain - pathology ; brain atrophy ; Continental Population Groups ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - pathology ; Fasting - blood ; Female ; Humans ; Insulin - blood ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Miscellaneous ; Nerve Fibers, Myelinated - pathology ; Nerve Fibers, Unmyelinated - pathology ; Nervous system ; obesity ; Obesity - blood ; Obesity - pathology ; Organ Size ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Regression Analysis ; Sex Factors ; tensor-based morphometry
É parte de: Human brain mapping, 2010-03, Vol.31 (3), p.353-364
Notas: NCRR - No. AG016570; No. EB01651; No. RR019771
NIA
ArticleID:HBM20870
American Heart Association - No. 0815465D
ark:/67375/WNG-3CFDSD2F-L
NIBIB
National Institute of Aging - No. AG 20098; No. AG05133; No. AG15928
istex:494DED4F393E575A2BCFBF8508F18AAA344B4FB6
Cyrus A. Raji and April J. Ho contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Obesity is associated with increased risk for cardiovascular health problems including diabetes, hypertension, and stroke. These cardiovascular afflictions increase risk for cognitive decline and dementia, but it is unknown whether these factors, specifically obesity and Type II diabetes, are associated with specific patterns of brain atrophy. We used tensor‐based morphometry (TBM) to examine gray matter (GM) and white matter (WM) volume differences in 94 elderly subjects who remained cognitively normal for at least 5 years after their scan. Bivariate analyses with corrections for multiple comparisons strongly linked body mass index (BMI), fasting plasma insulin (FPI) levels, and Type II Diabetes Mellitus (DM2) with atrophy in frontal, temporal, and subcortical brain regions. A multiple regression model, also correcting for multiple comparisons, revealed that BMI was still negatively correlated with brain atrophy (FDR <5%), while DM2 and FPI were no longer associated with any volume differences. In an Analysis of Covariance (ANCOVA) model controlling for age, gender, and race, obese subjects with a high BMI (BMI > 30) showed atrophy in the frontal lobes, anterior cingulate gyrus, hippocampus, and thalamus compared with individuals with a normal BMI (18.5–25). Overweight subjects (BMI: 25–30) had atrophy in the basal ganglia and corona radiata of the WM. Overall brain volume did not differ between overweight and obese persons. Higher BMI was associated with lower brain volumes in overweight and obese elderly subjects. Obesity is therefore associated with detectable brain volume deficits in cognitively normal elderly subjects. Hum Brain Mapp, 2010. © 2009 Wiley‐Liss, Inc.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Brain structure and obesity

Raji, Cyrus A. ; Ho, April J. ; Parikshak, Neelroop N. ; Becker, James T. ; Lopez, Oscar L. ; Kuller, Lewis H. ; Hua, Xue ; Leow, Alex D. ; Toga, Arthur W. ; Thompson, Paul M.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Buscando em bases de dados remotas. Favor aguardar.