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In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative

Lucarini, Rodrigo ; Bernardes, Wagner A. ; Ferreira, Daniele S. ; Tozatti, Marcos G. ; Furtado, Ricardo ; Bastos, Jairo K. ; Pauletti, Patrícia M. ; Januário, Ana H. ; Silva, Márcio L. Andrade e ; Cunha, Wilson R.

Pharmaceutical biology, 2013-09, Vol.51 (9), p.1087-1090 [Periódico revisado por pares]

England: Informa Healthcare USA, Inc

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Título:
In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative
Autor: Lucarini, Rodrigo ; Bernardes, Wagner A. ; Ferreira, Daniele S. ; Tozatti, Marcos G. ; Furtado, Ricardo ; Bastos, Jairo K. ; Pauletti, Patrícia M. ; Januário, Ana H. ; Silva, Márcio L. Andrade e ; Cunha, Wilson R.
Assuntos: Acetylation ; Administration, Oral ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - isolation & purification ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Antinociceptive activity ; Behavior, Animal - drug effects ; Brazil ; Cinnamates - administration & dosage ; Cinnamates - chemistry ; Cinnamates - isolation & purification ; Cinnamates - therapeutic use ; Depsides - administration & dosage ; Depsides - chemistry ; Depsides - isolation & purification ; Depsides - therapeutic use ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ethnopharmacology ; formalin test ; Lamiaceae ; Male ; Medicine, Traditional ; Mice ; Neuralgia - prevention & control ; Neurogenic Inflammation - prevention & control ; paw edema ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - therapeutic use ; Plant Leaves - chemistry ; Plant Stems - chemistry ; Rats ; Rats, Wistar ; Rosmarinic Acid ; Rosmarinus - chemistry
É parte de: Pharmaceutical biology, 2013-09, Vol.51 (9), p.1087-1090
Descrição: Abstract Context: Despite several pharmacological applications of Rosmarinus officinalis L. (Lamiaceae), studies on its analgesic and anti-inflammatory properties have been scarce. Objective: The aim of this work was to use in vivo models to evaluate the analgesic and anti-inflammatory activities of the aqueous extracts obtained from leaves (AEL) and stems (AES) of Rosmarinus officinalis, as well as its isolated compound - rosmarinic acid (RA). We also prepared and assessed the acetyl ester derivative of RA. Materials and methods: The analgesic activity was evaluated using abdominal constriction and formalin tests. For the evaluation of the anti-inflammatory effects, carrageenin-induced paw edema in rats were used. The extracts were used at doses of 100, 200 and 400 mg kg−1 compounds were tested at 10, 20 and 40 mg kg−1. Results: Orally administered AEL, AES and RA were not significantly active at any of the doses tested during the abdominal constriction test; the acetyl ester derivative of RA displayed significant analgesic activity. In the carrageenin-induced paw edema assay, the acetyl derivative of RA at all the tested doses produced significant anti-inflammatory effects and reduced the number of paw licks in the second phase of the formalin test. Discussion and conclusion: The results suggest that the analgesic effects of the acetyl derivative of RA operate via a peripheral-mediated mechanism. The acetyl ester derivative of RA is potentially applicable as a new lead compound for the management of pain and inflammation.
Editor: England: Informa Healthcare USA, Inc
Idioma: Inglês

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In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extracts, rosmarinic acid and its acetyl ester derivative

Lucarini, Rodrigo ; Bernardes, Wagner A. ; Ferreira, Daniele S. ; Tozatti, Marcos G. ; Furtado, Ricardo ; Bastos, Jairo K. ; Pauletti, Patrícia M. ; Januário, Ana H. ; Silva, Márcio L. Andrade e ; Cunha, Wilson R.

England: Informa Healthcare USA, Inc

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