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Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

Wahl, A S ; Omlor, W ; Rubio, J C ; Chen, J L ; Zheng, H ; Schröter, A ; Gullo, M ; Weinmann, O ; Kobayashi, K ; Helmchen, F ; Ommer, B ; Schwab, M E

Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6189), p.1250-1255 [Periódico revisado por pares]

United States

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Título:
Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke
Autor: Wahl, A S ; Omlor, W ; Rubio, J C ; Chen, J L ; Zheng, H ; Schröter, A ; Gullo, M ; Weinmann, O ; Kobayashi, K ; Helmchen, F ; Ommer, B ; Schwab, M E
Assuntos: Animals ; Female ; Immunotherapy - methods ; Motor Cortex - physiopathology ; Myelin Proteins - antagonists & inhibitors ; Nogo Proteins ; Physical Conditioning, Animal ; Prosencephalon - physiopathology ; Pyramidal Tracts - injuries ; Pyramidal Tracts - physiology ; Rats ; Rats, Long-Evans ; Recovery of Function ; Stroke Rehabilitation
É parte de: Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6189), p.1250-1255
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The brain exhibits limited capacity for spontaneous restoration of lost motor functions after stroke. Rehabilitation is the prevailing clinical approach to augment functional recovery, but the scientific basis is poorly understood. Here, we show nearly full recovery of skilled forelimb functions in rats with large strokes when a growth-promoting immunotherapy against a neurite growth-inhibitory protein was applied to boost the sprouting of new fibers, before stabilizing the newly formed circuits by intensive training. In contrast, early high-intensity training during the growth phase destroyed the effect and led to aberrant fiber patterns. Pharmacogenetic experiments identified a subset of corticospinal fibers originating in the intact half of the forebrain, side-switching in the spinal cord to newly innervate the impaired limb and restore skilled motor function.
Editor: United States
Idioma: Inglês

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Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke

Wahl, A S ; Omlor, W ; Rubio, J C ; Chen, J L ; Zheng, H ; Schröter, A ; Gullo, M ; Weinmann, O ; Kobayashi, K ; Helmchen, F ; Ommer, B ; Schwab, M E

United States

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