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Neutrophils instruct homeostatic and pathological states in naive tissues

Casanova-Acebes, Maria ; Nicolás-Ávila, José A ; Li, Jackson LiangYao ; García-Silva, Susana ; Balachander, Akhila ; Rubio-Ponce, Andrea ; Weiss, Linnea A ; Adrover, José M ; Burrows, Kyle ; A-González, Noelia ; Ballesteros, Ivan ; Devi, Sapna ; Quintana, Juan A ; Crainiciuc, Georgiana ; Leiva, Magdalena ; Gunzer, Matthias ; Weber, Christian ; Nagasawa, Takashi ; Soehnlein, Oliver ; Merad, Miriam ; Mortha, Arthur ; Ng, Lai Guan ; Peinado, Hector ; Hidalgo, Andrés

The Journal of experimental medicine, 2018-11, Vol.215 (11), p.2778-2795 [Periódico revisado por pares]

United States: Rockefeller University Press

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  • Título:
    Neutrophils instruct homeostatic and pathological states in naive tissues
  • Autor: Casanova-Acebes, Maria ; Nicolás-Ávila, José A ; Li, Jackson LiangYao ; García-Silva, Susana ; Balachander, Akhila ; Rubio-Ponce, Andrea ; Weiss, Linnea A ; Adrover, José M ; Burrows, Kyle ; A-González, Noelia ; Ballesteros, Ivan ; Devi, Sapna ; Quintana, Juan A ; Crainiciuc, Georgiana ; Leiva, Magdalena ; Gunzer, Matthias ; Weber, Christian ; Nagasawa, Takashi ; Soehnlein, Oliver ; Merad, Miriam ; Mortha, Arthur ; Ng, Lai Guan ; Peinado, Hector ; Hidalgo, Andrés
  • Assuntos: Medicin och hälsovetenskap
  • É parte de: The Journal of experimental medicine, 2018-11, Vol.215 (11), p.2778-2795
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    M. Casanova-Acebes, J.A. Nicolás-Ávila, and J.L. Li contributed equally to this paper.
    N. A-González’s present address is Institute for Immunology, University of Münster, Münster, Germany.
    L.A. Weiss’s present address is Centro Nacional de Biotecnología, Madrid, Spain.
    M. Casanova-Acebes’s present address is Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY.
  • Descrição: Immune protection relies on the capacity of neutrophils to infiltrate challenged tissues. Naive tissues, in contrast, are believed to remain free of these cells and protected from their toxic cargo. Here, we show that neutrophils are endowed with the capacity to infiltrate multiple tissues in the steady-state, a process that follows tissue-specific dynamics. By focusing in two particular tissues, the intestine and the lungs, we find that neutrophils infiltrating the intestine are engulfed by resident macrophages, resulting in repression of transcription, reduced G-CSF in plasma, and reinforced activity of distant bone marrow niches. In contrast, diurnal accumulation of neutrophils within the pulmonary vasculature influenced circadian transcription in the lungs. Neutrophil-influenced transcripts in this organ were associated with carcinogenesis and migration. Consistently, we found that neutrophils dictated the diurnal patterns of lung invasion by melanoma cells. Homeostatic infiltration of tissues unveils a facet of neutrophil biology that supports organ function, but can also instigate pathological states.
  • Editor: United States: Rockefeller University Press
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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