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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

Pappu, Rajita ; Schwab, Susan R ; Cornelissen, Ivo ; Pereira, João P ; Regard, Jean B ; Xu, Ying ; Camerer, Eric ; Zheng, Yao-Wu ; Huang, Yong ; Cyster, Jason G ; Coughlin, Shaun R

Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5822), p.295-298 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Autor: Pappu, Rajita ; Schwab, Susan R ; Cornelissen, Ivo ; Pereira, João P ; Regard, Jean B ; Xu, Ying ; Camerer, Eric ; Zheng, Yao-Wu ; Huang, Yong ; Cyster, Jason G ; Coughlin, Shaun R
Assuntos: Animals ; B lymphocytes ; Biological and medical sciences ; Blood ; Blood plasma ; Blood transfusion ; Bone Marrow - metabolism ; Chemotaxis, Leukocyte - physiology ; Chromatography, Liquid ; Endothelium, Vascular ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Genetics of the immune response ; Hematopoietic Stem Cells - metabolism ; Immune system ; Immunobiology ; Kinases ; Lymph ; Lymph nodes ; Lymphocytes ; Lymphocytes - metabolism ; Lymphocytes - physiology ; Lysophospholipids - biosynthesis ; Lysophospholipids - blood ; Lysophospholipids - deficiency ; Lysophospholipids - physiology ; Male ; Mice ; Mice, Inbred C57BL ; Phosphates ; Phosphotransferases (Alcohol Group Acceptor) - genetics ; Phosphotransferases (Alcohol Group Acceptor) - metabolism ; Receptors, Lysosphingolipid - physiology ; Rodents ; Signal transduction ; Sphingosine - analogs & derivatives ; Sphingosine - biosynthesis ; Sphingosine - blood ; Sphingosine - deficiency ; Sphingosine - physiology ; Spleen ; T lymphocytes ; Tandem Mass Spectrometry ; Thymocytes
É parte de: Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5822), p.295-298
Notas: http://www.scienceonline.org/
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Descrição: Lymphocytes require sphingosine-1-phosphate (S1P) receptor-1 to exit lymphoid organs, but the source(s) of extracellular S1P and whether S1P directly promotes egress are unknown. By using mice in which the two kinases that generate S1P were conditionally ablated, we find that plasma S1P is mainly hematopoietic in origin, with erythrocytes a major contributor, whereas lymph S1P is from a distinct radiation-resistant source. Lymphocyte egress from thymus and secondary lymphoid organs was markedly reduced in kinase-deficient mice. Restoration of S1P to plasma rescued egress to blood but not lymph, and the rescue required lymphocyte expression of S1P-receptor-1. Thus, separate sources provide S1P to plasma and lymph to help lymphocytes exit the low-S1P environment of lymphoid organs. Disruption of compartmentalized S1P signaling is a plausible mechanism by which S1P-receptor-1 agonists function as immunosuppressives.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

Pappu, Rajita ; Schwab, Susan R ; Cornelissen, Ivo ; Pereira, João P ; Regard, Jean B ; Xu, Ying ; Camerer, Eric ; Zheng, Yao-Wu ; Huang, Yong ; Cyster, Jason G ; Coughlin, Shaun R

Washington, DC: American Association for the Advancement of Science

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