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Association between proteinuria and incident colorectal cancer: analysis of a nationwide population-based database

Matsuoka, Satoshi ; Kaneko, Hidehiro ; Okada, Akira ; Fukui, Akira ; Yano, Yuichiro ; Itoh, Hidetaka ; Morita, Kojiro ; Fujiu, Katsuhito ; Michihata, Nobuaki ; Jo, Taisuke ; Takeda, Norifumi ; Morita, Hiroyuki ; Yamaguchi, Satoko ; Nakamura, Sunao ; Nishiyama, Akira ; Yokoo, Takashi ; Node, Koichi ; Yamauchi, Toshimasa ; Nangaku, Masaomi ; Yasunaga, Hideo ; Komuro, Issei

BMJ open, 2022-04, Vol.12 (4), p.e056250-e056250 [Periódico revisado por pares]

England: British Medical Journal Publishing Group

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Título:
Association between proteinuria and incident colorectal cancer: analysis of a nationwide population-based database
Autor: Matsuoka, Satoshi ; Kaneko, Hidehiro ; Okada, Akira ; Fukui, Akira ; Yano, Yuichiro ; Itoh, Hidetaka ; Morita, Kojiro ; Fujiu, Katsuhito ; Michihata, Nobuaki ; Jo, Taisuke ; Takeda, Norifumi ; Morita, Hiroyuki ; Yamaguchi, Satoko ; Nakamura, Sunao ; Nishiyama, Akira ; Yokoo, Takashi ; Node, Koichi ; Yamauchi, Toshimasa ; Nangaku, Masaomi ; Yasunaga, Hideo ; Komuro, Issei
Assuntos: Adult ; Age ; Alcohol ; Blood pressure ; Cancer therapies ; Cigarettes ; Codes ; Colorectal cancer ; Colorectal Neoplasms - complications ; Colorectal Neoplasms - epidemiology ; Creatinine ; Diabetes ; Epidemiology ; Glomerular Filtration Rate ; Humans ; Hypertension ; Hypertension - drug therapy ; Kidney diseases ; Nephrology ; Obesity ; ONCOLOGY ; Population ; PREVENTIVE MEDICINE ; Proteins ; Proteinuria - complications ; Renal replacement therapy ; Risk Factors ; Smoking ; Urine ; Young Adult
É parte de: BMJ open, 2022-04, Vol.12 (4), p.e056250-e056250
Notas: Original research
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Descrição: ObjectivesThis study aimed to assess whether adults with proteinuria were at a higher risk of incident colorectal cancer (CRC) than those without proteinuria using a large-scale population-based database.DesignA retrospective observational study.SettingThe JMDC Claims Database, an administrative health claims database, was used. Data were collected between 2005 and 2020.ParticipantsWe selected records of participants (n=3 543 705) who underwent health check-ups, including physical examinations, blood tests and urine dipstick tests. We excluded participants who were aged <20 years (n=25 577), had a history of CRC, colorectal disease, renal disease and renal replacement therapy (n=114 888), or had missing data on medications (n=170 145), cigarette smoking (n=14 835), alcohol consumption (n=366 414) or physical activity (n=106 550). Finally, we analysed 2 745 296 participants.Main outcome measuresThe primary outcome was CRC at any stage.ResultsParticipants were categorised as having no proteinuria (n=2 435 872), trace proteinuria (n=231 153) or positive proteinuria (n=78 271). Over a mean follow-up period of 1189±914 days, 10 615 CRC diagnoses were recorded. The incidence of CRC (95% CI) was lowest in participants without proteinuria (11.7; 95% CI, 11.5 to 11.9 per 10 000 person-years), followed by trace proteinuria (12.5; 95% CI, 11.7 to 13.3 per 10 000 person-years) and positive proteinuria (16.1; 95% CI, 14.6 to 17.7 per 10 000 person-years). After multivariable adjustment, compared with no proteinuria, HRs for incident CRC were 1.20 (95% CI, 1.12 to 1.29) and 1.23 (95% CI, 1.11 to 1.36) for trace and positive proteinuria, respectively. The association between proteinuria and incident CRC existed in participants after multiple imputations for missing data, with a follow-up period of ≥365 days, regardless of age, sex, obesity, hypertension, diabetes mellitus and estimated glomerular filtration rate.ConclusionsTrace and positive proteinuria were associated with a greater risk of incident CRC. Assessment of proteinuria could help identify individuals at an increased risk of CRC.
Editor: England: British Medical Journal Publishing Group
Idioma: Inglês

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Association between proteinuria and incident colorectal cancer: analysis of a nationwide population-based database

England: British Medical Journal Publishing Group

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