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A PCR-Based Linkage Map of Human Chromosome 1

Engelstein, Marcy ; Hudson, Thomas J. ; Lane, Joan M. ; Lee, Matthias K. ; Leverone, Ben ; Landes, Gregory M. ; Peltonen, Elena ; Weber, James L. ; Dracopoli, Nicholas C.

Genomics (San Diego, Calif.), 1993-02, Vol.15 (2), p.251-258 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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Título:
A PCR-Based Linkage Map of Human Chromosome 1
Autor: Engelstein, Marcy ; Hudson, Thomas J. ; Lane, Joan M. ; Lee, Matthias K. ; Leverone, Ben ; Landes, Gregory M. ; Peltonen, Elena ; Weber, James L. ; Dracopoli, Nicholas C.
Assuntos: Base Sequence ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL MARKERS ; Chromosome Mapping ; CHROMOSOMES ; Chromosomes, Human, Pair 1 ; Classical genetics, quantitative genetics, hybrids ; DISEASES ; DISTANCE ; DNA, Single-Stranded ; Female ; Fundamental and applied biological sciences. Psychology ; GENES ; Genetic Linkage ; GENETIC MAPPING ; Genetics of eukaryotes. Biological and molecular evolution ; Heterozygote ; Human ; HUMAN CHROMOSOMES ; Humans ; Male ; MAPPING 550400 -- Genetics ; Molecular Sequence Data ; Polymerase Chain Reaction ; RFLPS ; SCREENING
É parte de: Genomics (San Diego, Calif.), 1993-02, Vol.15 (2), p.251-258
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: A genetic linkage map of human chromosome 1 based entirely on PCR-typable markers has been developed using 38 simple sequence repeat (SSR) polymorphisms. These SSRs include 36 dinucleotide repeats and 2 tetranucleotide repeats. The average heterozygosity at these markers was 0.73 and ranged from 0.52 to 0.95. Multipoint linkage analysis was used to develop a map of these 38 markers in which the relative placement of each locus is supported by likelihood odds >1000:1. This PCR-based map was anchored at the centromere by the D1Z5 α-satellite polymorphism, and the ends of the map were defined by D1Z2 and D1S68, which are the most distal loci in the CEPH consortium map of chromosome 1. The sex-averaged, male, and female maps extend for 328, 273, and 409 cM, respectively. The average distance between markers on the sex-averaged map is 8 cM, and the largest interval is 32 cM. This map of highly informative PCR-based markers will provide a rapid means of screening human chromosome 1 for the presence of disease genes.
Editor: San Diego, CA: Elsevier Inc
Idioma: Inglês

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A PCR-Based Linkage Map of Human Chromosome 1

Engelstein, Marcy ; Hudson, Thomas J. ; Lane, Joan M. ; Lee, Matthias K. ; Leverone, Ben ; Landes, Gregory M. ; Peltonen, Elena ; Weber, James L. ; Dracopoli, Nicholas C.

San Diego, CA: Elsevier Inc

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