Idioma:

The Synthesis of N, N'-Disubstituted 2, 5-Diamino-6-hydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenol Derivatives

MIYAKE, AKIO ; KURIKI, HISASHI ; ITOH, KATSUMI ; NISHIKAWA, MASAO ; OKA, YOSHIKAZU

Chemical and Pharmaceutical Bulletin, 1977/12/25, Vol.25(12), pp.3289-3300 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
The Synthesis of N, N'-Disubstituted 2, 5-Diamino-6-hydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenol Derivatives
Autor: MIYAKE, AKIO ; KURIKI, HISASHI ; ITOH, KATSUMI ; NISHIKAWA, MASAO ; OKA, YOSHIKAZU
Assuntos: β2-selectivity
É parte de: Chemical and Pharmaceutical Bulletin, 1977/12/25, Vol.25(12), pp.3289-3300
Descrição: In a search for a new type of β-adrenoceptor agonist, a series of N, N'-disubstituted 2, 5-diamino-6-hydroxy-1, 2, 3, 4-tetrahydro-1-naphthalenols (2a-q), in which the 5-hydroxyl group of the previously reported rigid catecholamine (1) was replaced by methylamino, dimethylamino, ethylamino, dimethylamino, methanesulfonylamino, ureido, and formamido groups, were synthesized from 6-benzyloxy-5-nitro-4, 3-dihydro-1 (2H)-naphthalenone (6). 5-Chloro-2-isopropylamino derivative (53) was also prepared using an intermediate of those syntheses. Biological results for the two derivatives (2d and 2e) are presented.
Editor: Tokyo: The Pharmaceutical Society of Japan
Idioma: Inglês

Voltar para lista de resultados