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Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson's disease by reducing oxidative stress

Pangeni, Rudra ; Sharma, Shrestha ; Mustafa, Gulam ; Ali, Javed ; Baboota, Sanjula

Nanotechnology, 2014-12, Vol.25 (48), p.485102-485102 [Revista revisada por pares]

Bristol: IOP Publishing

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Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson's disease by reducing oxidative stress
Autor: Pangeni, Rudra ; Sharma, Shrestha ; Mustafa, Gulam ; Ali, Javed ; Baboota, Sanjula
Materias: Animals ; Antioxidants - pharmacology ; Biological and medical sciences ; Biological Availability ; Biotechnology ; Brain ; Brain - drug effects ; Chemistry, Pharmaceutical ; Condensed matter: electronic structure, electrical, magnetic, and optical properties ; Emulsions - pharmacology ; Exact sciences and technology ; Female ; Fundamental and applied biological sciences. Psychology ; high pressure homogenization ; Male ; Management ; Medical services ; Metabolism ; Methods. Procedures. Technologies ; nanoemulsion ; Nanoemulsions ; Nanoparticles - administration & dosage ; Nanostructure ; Nanotechnology ; Optical properties and condensed-matter spectroscopy and other interactions of matter with particles and radiation ; Optical properties of low-dimensional, mesoscopic, and nanoscale materials and structures ; Others ; Oxidative Stress - drug effects ; Parkinson Disease - drug therapy ; Parkinson's disease ; Particle Size ; phase diagram ; Physics ; Polysorbates - pharmacology ; Rats ; Rats, Wistar ; release study ; resveratrol ; Sod ; Solubility ; Stilbenes - pharmacology ; Swine ; Various methods and equipments ; Viscosity ; Vitamin E ; Vitamin E - pharmacology
Es parte de: Nanotechnology, 2014-12, Vol.25 (48), p.485102-485102
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Resveratrol, a potent natural antioxidant, possesses a wide range of pharmacological activities, but its oral bioavailability is very low due to its extensive hepatic and presystemic metabolism. The aim of the present study was to formulate a kinetically stable nanoemulsion (o w) using vitamin E:sefsol (1:1) as the oil phase, Tween 80 as the surfactant and Transcutol P as the co-surfactant for the better management of Parkinson's disease. The nanoemulsion was prepared by a spontaneous emulsification method, followed by high-pressure homogenization. Ternary phase diagrams were constructed to locate the area of nanoemulsion. The prepared formulations were studied for globule size, zeta potential, refractive index, viscosity, surface morphology and in vitro and ex vivo release. The homogenized formulation, which contained 150 mg ml−1 of resveratrol, showed spherical globules with an average globule diameter of 102 1.46 nm, a least poly dispersity index of 0.158 0.02 and optimal zeta potential values of −35 0.02. The cumulative percentage drug release for the pre-homogenized resveratrol suspension, pre-homogenized nanoemulsion and post-homogenized nanoemulsion were 24.18 2.30%, 54.32 0.95% and 88.57 1.92%, respectively, after 24 h. The ex vivo release also showed the cumulative percentage drug release of 85.48 1.34% at 24 h. The antioxidant activity determined by using a DPPH assay showed high scavenging efficiency for the optimized formulation. Pharmacokinetic studies showed the higher concentration of the drug in the brain (brain blood ratio: 2.86 0.70) following intranasal administration of the optimized nanoemulsion. Histopathological studies showed decreased degenerative changes in the resveratrol nanoemulsion administered groups. The levels of GSH and SOD were significantly higher, and the level of MDA was significantly lower in the resveratrol nanoemulsion treated group.
Editor: Bristol: IOP Publishing
Idioma: Inglés

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Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson's disease by reducing oxidative stress

Pangeni, Rudra ; Sharma, Shrestha ; Mustafa, Gulam ; Ali, Javed ; Baboota, Sanjula

Bristol: IOP Publishing

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