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4-methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways

Carmo, Helena ; Remião, Fernando ; Carvalho, Félix ; Fernandes, Eduarda ; de Boer, Douwe ; dos Reys, Lesseps A ; de Lourdes Bastos, Maria

Toxicology and applied pharmacology, 2003-08, Vol.190 (3), p.262-271 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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Título:
4-methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways
Autor: Carmo, Helena ; Remião, Fernando ; Carvalho, Félix ; Fernandes, Eduarda ; de Boer, Douwe ; dos Reys, Lesseps A ; de Lourdes Bastos, Maria
Assuntos: 4-Methylthioamphetamine ; Adrenergic alpha-Antagonists - pharmacology ; Amphetamine derivatives ; Amphetamines - toxicity ; Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Body Temperature - physiology ; Catecholamines - physiology ; Drug addictions ; Hyperthermia ; Hyperthermia, Induced ; Male ; Medical sciences ; Methysergide - pharmacology ; Mice ; Mice, Inbred Strains ; Monoamine Oxidase - metabolism ; Monoamine Oxidase Inhibitors - pharmacology ; Pargyline - pharmacology ; Prazosin - pharmacology ; Receptors, Adrenergic - metabolism ; Receptors, Serotonin - metabolism ; Serotonin - physiology ; Serotonin Antagonists - pharmacology ; Toxicology
É parte de: Toxicology and applied pharmacology, 2003-08, Vol.190 (3), p.262-271
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: 4-Methylthioamphetamine (4-MTA), also known as p-methylthioamphetamine, is a new amphetamine derivative which in humans has been increasingly associated with severe intoxications and several deaths. As hyperthermia is considered to be one of the most life-threatening acute physiological consequences of amphetamine-related intoxications, it was our aim to determine whether 4-MTA induces changes in body temperature in a mouse model. Accordingly, we measured the subcutaneous temperature after acute administration of 4-MTA in CD1 mice. Because hyperthermia seems to result from the central and peripheral actions of catecholamines and serotonin (5-hydroxytriptamine or 5-HT), we also investigated the possible interactions of some catecholaminergic and serotonergic receptor blockers and the inhibition of monoamine oxidase (MAO) with this effect. 4-MTA induced hyperthermia in CD1 mice. Blockade of the 5-HT receptors with methysergide and MAO inhibition with pargyline resulted in the potentiation of the 4-MTA-induced hyperthermic effect. Blockade of the α 1-adrenergic receptors with prazosin completely reverted the 4-MTA-induced hyperthermia while with the β-adrenergic receptor blocker dl-propranolol this reversal was not complete. Blockade of the α 2-adrenergic receptors with yohimbine had no effect on the hyperthermia induced by 4-MTA. These results suggest that 4-MTA-induced hyperthermia is highly influenced by the catecholaminergic and serotonergic receptor activation and the MAO activity.
Editor: San Diego, CA: Elsevier Inc
Idioma: Inglês

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4-methylthioamphetamine-induced hyperthermia in mice: influence of serotonergic and catecholaminergic pathways

Carmo, Helena ; Remião, Fernando ; Carvalho, Félix ; Fernandes, Eduarda ; de Boer, Douwe ; dos Reys, Lesseps A ; de Lourdes Bastos, Maria

San Diego, CA: Elsevier Inc

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