The chemical interaction between the neurotransmitter dopamine and the antipsychotic drugs olanzapine and quetiapine

• Autor: Bacil, Raphael P. ; de O. Marcondes Filho, Estenio A. ; de A. Dias, Kevin ; Portes, Marcelo C. ; de Araujo, William R. ; Oliveira-Silva, Diogo ; dos Santos, Alcindo A. ; Serrano, Silvia H.P.
• Assuntos: Buffer solutions ; Catechol ; Chemical interaction ; Chemical kinetics ; Chemical reactions ; Dopamine ; Drugs ; Electrochemical oxidation ; Mental disorders ; Model testing ; Neurotransmitters ; Olanzapine ; Psychotropic drugs ; Quetiapine ; Rate constants ; Schizophrenia ; Voltammetry
• É parte de: Journal of electroanalytical chemistry (Lausanne, Switzerland), 2021-01, Vol.881, p.114946, Article 114946
• Descrição: Mental disorders like schizophrenia affect about 0.7% of the world population. Nowadays, the treatment consists of atypical antipsychotic drugs, mainly olanzapine and quetiapine. In this paper, we observed the chemical interaction between both olanzapine and quetiapine, antipsychotic drugs, with dopamine in phosphate buffer solutions at physiological pH using cyclic and differential voltammetry techniques, UV–Vis and EPR spectra. A solution containing both antipsychotic drugs and dopamine resulted in a shift of dopamine's redox processes, hindering its electrochemical oxidation. The chemical interaction was voltametrically investigated and a mechanism is proposed. In addition, it was observed that the reactions of both drugs with DA are first-order, presenting kinetic rate constants of 1.5 10−2 s−1 and 9.0 10−3 s−1 for olanzapine and quetiapine, respectively, at pH = 7.4. To further evaluate the chemical reaction, a minimalist model between PIPES molecule and catechol was proposed and tested. The model presented a similar signal decrease and kinetic rate constant to those observed for both olanzapine and quetiapine reaction with dopamine, reinforcing the data obtained which strongly suggests that the chemical reaction occurs between piperazine and catechol moieties. [Display omitted] •Neurotransmitter dopamine reacts with antipsychotic drugs olanzapine and quetiapine;•The reaction occurs between the catechol and piperazine moieties from dopamine and the antipsychotics, respectively•A mechanism to the reactions involving both olanzapine and quetiapine with dopamine is proposed;•The reaction rate constants were obtained.
  
• Editor: Amsterdam: Elsevier B.V
  
• Idioma: Inglês