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31P NMR Studies of Control of Mitochondrial Function in Phosphofructokinase-Deficient Human Skeletal Muscle

Chance, B. ; Eleff, S. ; Bank, W. ; Leigh, J. S. ; Warnell, R.

Proceedings of the National Academy of Sciences - PNAS, 1982-12, Vol.79 (24), p.7714-7718 [Periódico revisado por pares]

United States: National Academy of Sciences of the United States of America

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Título:
31P NMR Studies of Control of Mitochondrial Function in Phosphofructokinase-Deficient Human Skeletal Muscle
Autor: Chance, B. ; Eleff, S. ; Bank, W. ; Leigh, J. S. ; Warnell, R.
Assuntos: Adenosine Diphosphate - metabolism ; Arm ; Biochemistry ; Bone metabolism ; Cellular metabolism ; Energy metabolism ; Humans ; Kinetics ; Legs ; Magnetic Resonance Spectroscopy ; Magnets ; Mitochondria, Muscle - metabolism ; Phosphates ; Phosphates - metabolism ; Phosphocreatine - metabolism ; Phosphofructokinase-1 - deficiency ; Physical Exertion ; Sugar Phosphates - metabolism ; Tumors
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1982-12, Vol.79 (24), p.7714-7718
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: Metabolic control of mitochondrial respiratory activity by Piand ADP has been evaluated by31P NMR measurements of the levels of Piin normal exercising human skeletal tissues in the resting-active-resting transition and, in this contribution, in the phosphofructokinase (PFK)-deficient leg. The latter studies show near constancy of Piin the recovery from maximal exercise of the leg, with large changes of sugar phosphate (SP) complementary to the changes of phosphocreatine (PCr). The PFK deficiency permits observation of PCr resynthesis in postexercise recovery under conditions of nearly constant Piand ATP--a phenomenon not evident in normal exercising muscle. The constancy of free Piis inconsistent with its role in control of mitochondrial activity, leaving ADP as a key metabolic control element. These results help clarify previous controversies on the nature of control of metabolic activity of mitochondria and extend the idea of ADP control of mitochondrial metabolic states in vivo and, in addition, provide an appropriate exercise protocol for the evaluation of a genetic deficiency affecting mitochondrial metabolism.
Editor: United States: National Academy of Sciences of the United States of America
Idioma: Inglês

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31P NMR Studies of Control of Mitochondrial Function in Phosphofructokinase-Deficient Human Skeletal Muscle

Chance, B. ; Eleff, S. ; Bank, W. ; Leigh, J. S. ; Warnell, R.

United States: National Academy of Sciences of the United States of America

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