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Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications

Abdullah ; Hussain, Tahir ; Faisal, Shah ; Rizwan, Muhammad ; Almostafa, Mervt M ; Younis, Nancy S ; Yahya, Galal

BMC complementary and alternative medicine, 2023-10, Vol.23 (1), p.349-349, Article 349 [Periódico revisado por pares]

England: BioMed Central Ltd

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Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications
Autor: Abdullah ; Hussain, Tahir ; Faisal, Shah ; Rizwan, Muhammad ; Almostafa, Mervt M ; Younis, Nancy S ; Yahya, Galal
Assuntos: alpha-Amylases ; Amylases ; Antibacterial agents ; Antidiabetics ; Antimicrobial ; Antioxidant ; Antioxidants ; Antiparasitic agents ; Aquatic plants ; Assaying ; Bacteria ; Biocompatibility ; Biocompatible ; Cancer ; Cytotoxicity ; Diabetes mellitus ; Diffraction ; Dyes ; E coli ; Electron microscopes ; Escherichia coli ; Ethylenediaminetetraacetic acid ; Fourier transforms ; Free radicals ; Free radicals (Chemistry) ; Gentian violet ; Ginger ; Glucosidase ; Grain size ; Health aspects ; Hypoglycemic Agents - pharmacology ; Infrared spectroscopy ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - toxicity ; Micrography ; Nanoparticles ; Nanotechnology ; Nickel ; Pharmacology ; Photocatalysis ; Photomicrographs ; Reducing agents ; Rhizome ; Rhizomes ; Scanning electron microscopy ; Scavenging ; Spectrum analysis ; Stabilizers (agents) ; X ray powder diffraction ; X-ray spectroscopy ; X-rays ; Zingiber officinale ; α-Amylase ; α-Glucosidase
É parte de: BMC complementary and alternative medicine, 2023-10, Vol.23 (1), p.349-349, Article 349
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Zingiber officinale, generally known as ginger, contains bioactive phytochemicals, including gingerols and shogaols, that may function as reducing agents and stabilizers for the formation of nickel nanoparticles (Ni-NPs). Ginger extract-mediated nickel nanoparticles were synthesized using an eco-friendly method, and their antibacterial, antioxidant, antiparasitic, antidiabetic, anticancer, dye degrading, and biocompatibility properties were investigated. UV-visible spectroscopy, fourier transform infrared spectroscopy, X-ray powder diffraction, energy-dispersive X-ray spectroscopy, and scanning electron microscopy were used to validate and characterize the synthesis of Ni-NPs. Agar well diffusion assay, alpha-amylase and glucosidase inhibitory assay, free radical scavenging assay, biocompatibility assay, and MTT assay were used to analyse the biomedical importance of Ni-NPs. SEM micrograph examinations revealed almost aggregates of Ni-NPs; certain particles were monodispersed and spherical, with an average grain size of 74.85 ± 2.5 nm. Ni-NPs have successfully inhibited the growth of Pseudomonas aeruginosa, Escherichia coli, and Proteus vulgaris by inducing membrane damage, as shown by the absorbance at 260 nm (A260). DPPH (2,2-diphenyl-1-picrylhydrazyl) free radicals were successfully scavenged by Ni-NPs at an inhibition rate of 69.35 ± 0.81% at 800 µg/mL. A dose-dependent cytotoxicity of Ni-NPs was observed against amastigote and promastigote forms of Leishmania tropica, with significant mortality rates of 94.23 ± 1.10 and 92.27 ± 1.20% at 1.0 mg/mL, respectively. Biocompatibility studies revealed the biosafe nature of Ni-NPs by showing RBC hemolysis up to 1.53 ± 0.81% at 400 µg/mL, which is considered safe according to the American Society for Materials and Testing (ASTM). Furthermore, Ni-NPs showed antidiabetic activity by inhibiting α-amylase and α-glucosidase enzymes at an inhibition rate of 22.70 ± 0.16% and 31.23 ± 0.64% at 200 µg/mL, respectively. Ni-NPs have shown significant cytotoxic activity by inhibiting MCF-7 cancerous cells up to 68.82 ± 1.82% at a concentration of 400 µg/mL. The IC50 for Ni-NPs was almost 190 µg/mL. Ni-NPs also degraded crystal violet dye up to 86.1% at 2 h of exposure. In conclusion, Zingiber officinale extract was found successful in producing stable nanoparticles. Ni-NPs have shown substantial biomedical activities, and as a result, we believe these nanoparticles have potential as a powerful therapeutic agent for use in nanomedicine.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Zingiber officinale rhizome extracts mediated ni nanoparticles and its promising biomedical and environmental applications

Abdullah ; Hussain, Tahir ; Faisal, Shah ; Rizwan, Muhammad ; Almostafa, Mervt M ; Younis, Nancy S ; Yahya, Galal

England: BioMed Central Ltd

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