Idioma:

Peripheral biomarkers and illness activity in bipolar disorder

Kapczinski, Flávio ; Dal-Pizzol, Felipe ; Teixeira, Antonio Lucio ; Magalhaes, Pedro V.S ; Kauer-Sant’Anna, Márcia ; Klamt, Fábio ; Moreira, José Claudio F ; Augusto de Bittencourt Pasquali, Mateus ; Fries, Gabriel Rodrigo ; Quevedo, João ; Gama, Clarissa Severino ; Post, Robert

Journal of psychiatric research, 2011-02, Vol.45 (2), p.156-161 [Revista revisada por pares]

Kidlington: Elsevier Ltd

Texto completo disponible

Citas Citado por

Acciones

Título:
Peripheral biomarkers and illness activity in bipolar disorder
Autor: Kapczinski, Flávio ; Dal-Pizzol, Felipe ; Teixeira, Antonio Lucio ; Magalhaes, Pedro V.S ; Kauer-Sant’Anna, Márcia ; Klamt, Fábio ; Moreira, José Claudio F ; Augusto de Bittencourt Pasquali, Mateus ; Fries, Gabriel Rodrigo ; Quevedo, João ; Gama, Clarissa Severino ; Post, Robert
Materias: Adult ; Adult and adolescent clinical studies ; Aged ; Allostatic load ; Biological and medical sciences ; Biological markers ; Biomarkers ; Biomarkers - metabolism ; Bipolar affective disorder ; Bipolar disorder ; Bipolar Disorder - metabolism ; Bipolar Disorder - physiopathology ; Bipolar disorders ; Brain ; Brain-Derived Neurotrophic Factor - blood ; Case-Control Studies ; Cell death ; Cytokines - blood ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Humans ; Illness activity ; Illness Behavior ; Indexing in process ; Inflammation ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Moods ; Nervous system ; Neurotrophin 3 - blood ; Neurotrophins ; Oxidative stress ; Protein Carbonylation ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Sepsis ; Statistics as Topic ; Thiobarbituric Acid Reactive Substances - metabolism
Es parte de: Journal of psychiatric research, 2011-02, Vol.45 (2), p.156-161
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descripción: Abstract Recent evidence suggests that peripheral markers related to oxidative stress, inflammation and neurotrophins may be altered during mood episodes in bipolar disorder. These can be seen as proxies of peripheral toxicity or markers of illness activity. Here we report an en bloc assessment of a set of previously described biomarkers in different mood states ( n = 60) as well as in healthy subjects ( n = 80). To make the point that these are ominous changes, we obtained the same measures from a group of septic patients ( n = 15) as a “positive” control group. In this sample, we measured serum levels of brain derived neurotrophic factor, neurotrophin 3, tumor necrosis factor α, interleukin 6, interleukin 10, total reactive antioxidant potential, thiobarbituric acid reactive substances and protein carbonyl content. Several of the markers discriminated between the bipolar and control groups, especially when patients were in acute episodes. In some cases, toxicity was as high in bipolar disorder as that seen in patients with sepsis. We believe these findings highlight the potential of using biomarkers to assess illness activity in bipolar disorder.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglés

Enlaces

Volver a la lista de resultados

Anterior Resultado 3 Siguiente Ir a la siguiente página

Realización: Logos de Redes Sociales:

Peripheral biomarkers and illness activity in bipolar disorder

Kapczinski, Flávio ; Dal-Pizzol, Felipe ; Teixeira, Antonio Lucio ; Magalhaes, Pedro V.S ; Kauer-Sant’Anna, Márcia ; Klamt, Fábio ; Moreira, José Claudio F ; Augusto de Bittencourt Pasquali, Mateus ; Fries, Gabriel Rodrigo ; Quevedo, João ; Gama, Clarissa Severino ; Post, Robert

Kidlington: Elsevier Ltd

Buscando en bases de datos remotas, por favor espere