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Predictive value of MRI parameters in severity and recovery of first-episode myelitis in aquaporin-4 antibody disease

Murchison, Andrew ; Kitley, Joanna ; Leite, M. Isabel ; Küker, Wilhelm ; Palace, Jacqueline

Journal of the neurological sciences, 2015-08, Vol.355 (1), p.49-53 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Predictive value of MRI parameters in severity and recovery of first-episode myelitis in aquaporin-4 antibody disease
Autor: Murchison, Andrew ; Kitley, Joanna ; Leite, M. Isabel ; Küker, Wilhelm ; Palace, Jacqueline
Assuntos: Adult ; Aged ; Antibodies - blood ; AQP4 ; Aquaporin 4 - immunology ; Aquaporin-4 ; Disability ; Disability Evaluation ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neurology ; Neuromyelitis optica ; Neuromyelitis Optica - blood ; Neuromyelitis Optica - pathology ; Neuromyelitis Optica - therapy ; NMO ; Plasma Exchange - methods ; Predictive Value of Tests ; Recovery of Function - physiology ; Spinal Cord - pathology ; Statistics, Nonparametric ; Young Adult
É parte de: Journal of the neurological sciences, 2015-08, Vol.355 (1), p.49-53
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) associated with aquaporin-4 antibodies (AQP4-Ab) typically causes longitudinally-extensive transverse myelitis (LETM). Few data exist about the association of MRI features with LETM attack severity and recovery. Methods AQP4-Ab positive NMOSD patients with a first myelitis attack were retrospectively identified and spinal MRI scans reviewed. Association of MRI features with EDSS scores at attack nadir and recovery was evaluated. Results 22 patients were included. Median nadir EDSS score was 8 (range 1 to 8.5). Nadir EDSS scores correlated with total MRI lesion length (r = 0.48, p = 0.025), higher scores were seen in those with gadolinium enhancement (p = 0.025) and there was a trend towards higher scores with central cord involvement. The median recovery EDSS was 6 (range 0 to 10). Total lesion length correlated with poor recovery (r = 0.48, p = 0.027) but this was confounded by correlation between nadir and recovery EDSS scores. Conclusion We confirm that myelitis in AQP4-Ab disease is severe and show that the severity correlates with lesion length and residual disability. Spinal cord lesions in first myelitis attacks are similar to appearances reported later in the disease course, with propensity to involve the central grey matter and high frequency of cord oedema and T1 hypointensity.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Predictive value of MRI parameters in severity and recovery of first-episode myelitis in aquaporin-4 antibody disease

Murchison, Andrew ; Kitley, Joanna ; Leite, M. Isabel ; Küker, Wilhelm ; Palace, Jacqueline

Netherlands: Elsevier B.V

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