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Can We Really Accelerate and Enhance the Selective Serotonin Reuptake Inhibitor Antidepressant Effect? A Randomized Clinical Trial and a Meta-Analysis of Pindolol in Nonresistant Depression

PORTELLA, Maria J ; DE DIEGO-ADELINO, Javier ; BALLESTEROS, Javier ; PUIGDEMONT, Dolors ; OILER, Silvia ; SANTOS, Borja ; ALVAREZ, Enric ; ARTIGAS, Francesc ; PEREZ, Victor

The journal of clinical psychiatry, 2011-07, Vol.72 (7), p.962-969 [Periódico revisado por pares]

Memphis, TN: Physicians Postgraduate Press

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Título:
Can We Really Accelerate and Enhance the Selective Serotonin Reuptake Inhibitor Antidepressant Effect? A Randomized Clinical Trial and a Meta-Analysis of Pindolol in Nonresistant Depression
Autor: PORTELLA, Maria J ; DE DIEGO-ADELINO, Javier ; BALLESTEROS, Javier ; PUIGDEMONT, Dolors ; OILER, Silvia ; SANTOS, Borja ; ALVAREZ, Enric ; ARTIGAS, Francesc ; PEREZ, Victor
Assuntos: Administration, Oral ; Adrenergic beta-Antagonists - administration & dosage ; Adrenergic beta-Antagonists - adverse effects ; Adult ; Adult and adolescent clinical studies ; Antidepressive Agents, Second-Generation - administration & dosage ; Biological and medical sciences ; Citalopram - administration & dosage ; Depression ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - drug therapy ; Dose-Response Relationship, Drug ; Drug Synergism ; Drug Therapy, Combination ; Female ; Humans ; Infusions, Intravenous ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Neuropharmacology ; Personality Inventory - statistics & numerical data ; Pharmacology. Drug treatments ; Pindolol - administration & dosage ; Pindolol - adverse effects ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychometrics ; Psychopathology. Psychiatry ; Psychopharmacology ; Serotonin Antagonists - administration & dosage ; Serotonin Antagonists - adverse effects ; Serotonin Uptake Inhibitors - administration & dosage ; Time Factors ; Treatment Outcome
É parte de: The journal of clinical psychiatry, 2011-07, Vol.72 (7), p.962-969
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
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Descrição: Since depression entails not only dramatic personal disruption but also a huge amount of medical and socioeconomic burden, slowness of antidepressant action and difficulties to attain remission are entangled issues to be solved. Given the controversial previous findings with enhancing strategies such as pindolol, we examined whether the speed of selective serotonin reuptake inhibitor (SSRI) action can be truly accelerated with optimized pindolol dosage. Additionally, we aimed at elucidating whether pindolol benefits emerge, particularly in a population with nonresistant depression. Thirty outpatients with major depressive disorder (DSM-IV criteria) recruited between December 2002 and November 2005 were randomly assigned to receive citalopram + pindolol (5 mg tid) or citalopram + placebo for 6 weeks in a double-blind randomized clinical trial. A meta-analysis of randomized controlled trials of pindolol augmentation in patients with nonresistant depression was also performed. Outcome criteria were based on the 17-item Hamilton Depression Rating Scale. For the meta-analysis, efficacy was assessed by the number of treatment responders at 2 weeks and 4-6 weeks. Clinical trial outcomes: Repeated-measures analysis of variance showed a significant group-by-time interaction (P = .01). Cumulative percentage showed a trend for sustained response (odds ratio [OR] = 2.09; 95% CI, 0.914-4.780; P = .08) and a well-defined increased likelihood of sustaining remission (OR = 5.00; 95% CI, 1.191-20.989; P = .03) in pindolol receivers. Median survival time until first response was 65% less in the pindolol group (22 days vs 30 days; P = .03). The negative binomial regression model yielded different rates of response per person-day for pindolol and placebo groups (7.6% vs 4.7%, respectively; P = .03). Meta-analysis: Outcome favored pindolol at 2 weeks' time (relative risk [RR] = 1.68; 95% CI, 1.18-2.39; P = .004) and also at 4-6 weeks' time (RR = 1.11; 95% CI, 1.02-1.20; P = .02). Present findings represent further evidence of the acceleration and enhancement of efficacy with pindolol administered together with SSRIs, displaying a quicker and more pronounced decrease of symptoms in patients with nonresistant major depressive disorder. clinicaltrials.gov Identifier: NCT00931775.
Editor: Memphis, TN: Physicians Postgraduate Press
Idioma: Inglês

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Can We Really Accelerate and Enhance the Selective Serotonin Reuptake Inhibitor Antidepressant Effect? A Randomized Clinical Trial and a Meta-Analysis of Pindolol in Nonresistant Depression

PORTELLA, Maria J ; DE DIEGO-ADELINO, Javier ; BALLESTEROS, Javier ; PUIGDEMONT, Dolors ; OILER, Silvia ; SANTOS, Borja ; ALVAREZ, Enric ; ARTIGAS, Francesc ; PEREZ, Victor

Memphis, TN: Physicians Postgraduate Press

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