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Bone mineral density in children and adolescents with perinatal HIV infection

DIMEGLIO, Linda A ; JIAJIA WANG ; DYKE, Russell B. Van ; FIELDING, Roger A ; GURMU, Yared ; JACOBSON, Denise L ; SIBERRY, George K ; MILLER, Tracie L ; GEFFNER, Mitchell E ; HAZRA, Rohan ; BORKOWSKY, William ; CHEN, Janet S ; DOOLEY, Laurie ; PATEL, Kunjal

AIDS (London), 2013-01, Vol.27 (2), p.211-220 [Revista revisada por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Bone mineral density in children and adolescents with perinatal HIV infection
Autor: DIMEGLIO, Linda A ; JIAJIA WANG ; DYKE, Russell B. Van ; FIELDING, Roger A ; GURMU, Yared ; JACOBSON, Denise L ; SIBERRY, George K ; MILLER, Tracie L ; GEFFNER, Mitchell E ; HAZRA, Rohan ; BORKOWSKY, William ; CHEN, Janet S ; DOOLEY, Laurie ; PATEL, Kunjal
Materias: Absorptiometry ; Absorptiometry, Photon ; Adolescent ; Anti-Retroviral Agents - therapeutic use ; Antiretroviral Therapy, Highly Active - methods ; Biological and medical sciences ; Body Mass Index ; Bone Density - physiology ; CD4 Lymphocyte Count ; Child ; Cross-Sectional Studies ; Female ; Growth - physiology ; HIV Infections - diagnostic imaging ; HIV Infections - drug therapy ; HIV Infections - physiopathology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant, Newborn ; Infectious diseases ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Osteoarticular system. Muscles ; Predictive Value of Tests ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Regression Analysis ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load
Es parte de: AIDS (London), 2013-01, Vol.27 (2), p.211-220
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descripción: To estimate prevalence of low bone mineral density (BMD) in perinatally HIV-infected (HIV+) and HIV-exposed but uninfected (HEU) children, and to determine predictors of BMD in HIV+. Cross-sectional analysis within a 15-site United States and Puerto Rico cohort study. Total body and lumbar spine BMD were measured using dual energy-X-ray absorptiometry. BMD Z-scores accounted for bone age and sex. Multiple linear regression was used to evaluate differences in Z-scores by HIV status and for predictors of BMD in HIV+. 350 HIV+ and 160 HEU were enrolled. Mean age was 12.6 and 10.7 years for HIV+ and HEU, respectively. Most (87%) HIV+ were receiving HAART. More HIV+ than HEU had total body and lumbar spine Z-scores less than -2.0 (total body: 7 vs. 1%, P = 0.008; lumbar spine: 4 vs. 1%, P = 0.08). Average differences in Z-scores between HIV+ and HEU were attenuated after height and/or weight adjustment. Among HIV+, total body Z-scores were lower in those with higher CD4% and in those who ever used boosted protease inhibitors or lamivudine. Lumbar spine Z-scores were lower with higher peak viral load and CD4%, more years on HAART, and ever use of indinavir. Rates of low BMD in HIV+ children were greater than expected based on normal population distributions. These differences were partially explained by delays in growth. As most HIV+ children in this study had not entered their pubertal growth spurt, prepubertal factors associated with BMD, magnified or carried forward, may result in sub-optimal peak BMD in adulthood.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglés

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Bone mineral density in children and adolescents with perinatal HIV infection

DIMEGLIO, Linda A ; JIAJIA WANG ; DYKE, Russell B. Van ; FIELDING, Roger A ; GURMU, Yared ; JACOBSON, Denise L ; SIBERRY, George K ; MILLER, Tracie L ; GEFFNER, Mitchell E ; HAZRA, Rohan ; BORKOWSKY, William ; CHEN, Janet S ; DOOLEY, Laurie ; PATEL, Kunjal

Hagerstown, MD: Lippincott Williams & Wilkins

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