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Hypofractionation in Hepatocellular Carcinoma – The Effect of Fractionation Size

Lewis, S. ; Barry, A. ; Hawkins, M.A.

Clinical oncology (Royal College of Radiologists (Great Britain)), 2022-05, Vol.34 (5), p.e195-e209 [Periódico revisado por pares]

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Título:
Hypofractionation in Hepatocellular Carcinoma – The Effect of Fractionation Size
Autor: Lewis, S. ; Barry, A. ; Hawkins, M.A.
Assuntos: Carcinoma, Hepatocellular - radiotherapy ; Dose fractionation ; Dose Fractionation, Radiation ; External beam radiotherapy (EBRT) ; Hepatocellular carcinoma (HCC) ; Humans ; Hypofractionation ; Liver Neoplasms - radiotherapy ; Prospective Studies ; Radiation Dose Hypofractionation ; Radiosurgery - methods ; Radiotherapy ; Stereotactic body radiotherapy (SBRT)
É parte de: Clinical oncology (Royal College of Radiologists (Great Britain)), 2022-05, Vol.34 (5), p.e195-e209
Descrição: The use of stereotactic body radiotherapy (SBRT) in hepatocellular carcinoma (HCC) has increased over the years. Several prospective studies have demonstrated its safety and efficacy, and randomised trials are underway. The advancement in technology has enabled the transition from three-dimensional conformal radiotherapy to highly focused SBRT. Liver damage is the primary limiting toxicity with radiation, with the incidence of grade 3 varying from 0 to 30%. The reported radiotherapy fractionation schedule for HCC, and in practice use, ranges from one to 10 fractions, based on clinician preference and technology available, tumour location and tumour size. This review summarises the safety and efficacy of various SBRT fractionation schedules for HCC.
Editor: England: Elsevier Ltd
Idioma: Inglês

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