Idioma:

Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis

Caldieri, Giusi ; Barbieri, Elisa ; Nappo, Gilda ; Raimondi, Andrea ; Bonora, Massimo ; Conte, Alexia ; Verhoef, Lisette G. G. C. ; Confalonieri, Stefano ; Malabarba, Maria Grazia ; Bianchi, Fabrizio ; Cuomo, Alessandro ; Bonaldi, Tiziana ; Martini, Emanuele ; Mazza, Davide ; Pinton, Paolo ; Tacchetti, Carlo ; Polo, Simona ; Di Fiore, Pier Paolo ; Sigismund, Sara

Science (American Association for the Advancement of Science), 2017-05, Vol.356 (6338), p.617-624 [Periódico revisado por pares]

United States: American Association for the Advancement of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis
Autor: Caldieri, Giusi ; Barbieri, Elisa ; Nappo, Gilda ; Raimondi, Andrea ; Bonora, Massimo ; Conte, Alexia ; Verhoef, Lisette G. G. C. ; Confalonieri, Stefano ; Malabarba, Maria Grazia ; Bianchi, Fabrizio ; Cuomo, Alessandro ; Bonaldi, Tiziana ; Martini, Emanuele ; Mazza, Davide ; Pinton, Paolo ; Tacchetti, Carlo ; Polo, Simona ; Di Fiore, Pier Paolo ; Sigismund, Sara
Assuntos: Attenuation ; Basigin - metabolism ; Calcium channels ; Calcium ions ; Calcium Signaling ; Calcium signalling ; Cargo ; Carrier Proteins - metabolism ; CD147 antigen ; Cell Line ; Cell Membrane - metabolism ; Clathrin ; Contact ; Cortex ; Degradation ; Endocytosis ; Endoplasmic reticulum ; Endoplasmic Reticulum - metabolism ; Epidermal growth factor ; Epidermal growth factor receptors ; ErbB Receptors - metabolism ; Formations ; Growth factors ; Humans ; Inositol 1,4,5-trisphosphate receptors ; Inositols ; Integration ; Intermediates ; Internalization ; Invaginations ; Maturation ; Membrane Proteins - metabolism ; Membranes ; Molecular biology ; Nerve Tissue Proteins - metabolism ; Pathways ; Proteins ; Receptors ; Regulators ; Signal transduction ; Signaling
É parte de: Science (American Association for the Advancement of Science), 2017-05, Vol.356 (6338), p.617-624
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The integration of endocytic routes is critical to regulate receptor signaling. A nonclathrin endocytic (NCE) pathway of the epidermal growth factor receptor (EGFR) is activated at high ligand concentrations and targets receptors to degradation, attenuating signaling. Here we performed an unbiased molecular characterization of EGFR-NCE.We identified NCE-specific regulators, including the endoplasmic reticulum (ER)–resident protein reticulon 3 (RTN3) and a specific cargo, CD147. RTN3 was critical for EGFR/CD147-NCE, promoting the creation of plasma membrane (PM)–ER contact sites that were required for the formation and/or maturation of NCE invaginations. Ca2+ release at these sites, triggered by inositol 1,4,5-trisphosphate (IP₃)–dependent activation of ER Ca2+ channels, was needed for the completion of EGFR internalization. Thus, we identified a mechanism of EGFR endocytosis that relies on ER-PM contact sites and local Ca2+ signaling.
Editor: United States: American Association for the Advancement of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 3 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis

United States: American Association for the Advancement of Science

Buscando em bases de dados remotas. Favor aguardar.