skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Búsqueda General
Búsqueda Avanzada
Búsqueda por Índices

The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability

Marioni, Riccardo E. ; Penke, Lars ; Davies, Gail ; Huffman, Jennifer E. ; Hayward, Caroline ; Deary, Ian J.

Proceedings of the Royal Society. B, Biological sciences, 2014-04, Vol.281 (1781), p.20140117-20140117 [Revista revisada por pares]

England: The Royal Society

Texto completo disponible

Citas Citado por
  • Título:
    The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability
  • Autor: Marioni, Riccardo E. ; Penke, Lars ; Davies, Gail ; Huffman, Jennifer E. ; Hayward, Caroline ; Deary, Ian J.
  • Materias: Age Factors ; Aged ; Child ; Cohort Studies ; Exome ; Exome - genetics ; Fitness ; Gene Frequency ; General Cognitive Ability ; Genetic Burden ; Genetic Fitness - genetics ; Genetic Variation - genetics ; Genetic Variation - physiology ; Humans ; Intelligence ; Intelligence - genetics ; Linear Models ; Mutation - genetics ; Mutation–selection Balance ; Selection, Genetic ; Sex Factors
  • Es parte de: Proceedings of the Royal Society. B, Biological sciences, 2014-04, Vol.281 (1781), p.20140117-20140117
  • Notas: These authors contributed equally to this study.
    href:rspb20140117.pdf
    ArticleID:rspb20140117
    ark:/67375/V84-2G3C3MV4-X
    istex:E769E97392CB8CD567300AC14D530814D5D5FBDE
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descripción: Human cognitive ability shows consistent, positive associations with fitness components across the life-course. Underlying genetic variation should therefore be depleted by selection, which is not observed. Genetic variation in general cognitive ability (intelligence) could be maintained by a mutation–selection balance, with rare variants contributing to its genetic architecture. This study examines the association between the total number of rare stop-gain/loss, splice and missense exonic variants and cognitive ability in childhood and old age in the same individuals. Exome array data were obtained in the Lothian Birth Cohorts of 1921 and 1936 (combined N = 1596). General cognitive ability was assessed at age 11 years and in late life (79 and 70 years, respectively) and was modelled against the total number of stop-gain/loss, splice, and missense exonic variants, with minor allele frequency less than or equal to 0.01, using linear regression adjusted for age and sex. In both cohorts and in both the childhood and late-life models, there were no significant associations between rare variant burden in the exome and cognitive ability that survived correction for multiple testing. Contrary to our a priori hypothesis, we observed no evidence for an association between the total number of rare exonic variants and either childhood cognitive ability or late-life cognitive ability.
  • Editor: England: The Royal Society
  • Idioma: Inglés
Enlaces
Volver a la lista de resultados
Ir a la página anteriorAnterior Resultado  2 SiguienteIr a la siguiente página

  • Realización: ABCD-USP USP   Logos de Redes Sociales: Freepik

Buscando en bases de datos remotas, por favor espere

  • Buscando por
  • enscope:(USP_PRODUCAO),scope:(USP_EBOOKS),scope:("PRIMO"),scope:(USP),scope:(USP_EREVISTAS),scope:(USP_FISICO),primo_central_multiple_fe
  • Mostrar lo que tiene hasta ahora