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Resveratrol and inflammatory bowel disease

Shi, Yaning ; Zhou, Jie ; Jiang, Bo ; Miao, Ming

Annals of the New York Academy of Sciences, 2017-09, Vol.1403 (1), p.38-47 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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Título:
Resveratrol and inflammatory bowel disease
Autor: Shi, Yaning ; Zhou, Jie ; Jiang, Bo ; Miao, Ming
Assuntos: Anti-Inflammatory Agents - therapeutic use ; Antioxidants ; Antioxidants - therapeutic use ; Bioavailability ; Colon ; Crohn's disease ; Gastrointestinal tract ; Humans ; Immune response ; Immunology ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - drug therapy ; Intestine ; mechanism ; metabolites ; Microorganisms ; Pathogenesis ; Psychological factors ; Resveratrol ; Stilbenes - therapeutic use ; Structure-function relationships ; Therapeutic applications ; Treatment Outcome ; Ulcerative colitis
É parte de: Annals of the New York Academy of Sciences, 2017-09, Vol.1403 (1), p.38-47
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, comprising ulcerative colitis (UC) and Crohn's disease (CD). Progression of IBD leads to long‐term impairment of intestinal structure and function. The pathogenesis of IBD is complex, involving environmental, immunological, genetic, microbial, and psychological factors. The conventional therapies and many existing biopharmaceuticals for IBD have limited efficacy or adverse effects. As a promising safe and effective therapy for IBD, resveratrol has been studied widely, as it has shown anti‐inflammatory and antioxidant activity. Resveratrol's mechanism of action involves multiple immune responses and signaling pathways; it is absorbed quickly and metabolized into various derivatives. However, the poor water solubility and low bioavailability of resveratrol limit its clinical applications. Further research should attempt to improve the stability and oral bioavailability of resveratrol by modification and various delivery systems.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

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Resveratrol and inflammatory bowel disease

Shi, Yaning ; Zhou, Jie ; Jiang, Bo ; Miao, Ming

United States: Wiley Subscription Services, Inc

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