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The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice

Tristão, F S M ; Rocha, F A ; Dias, F C ; Rossi, M A ; Silva, J S

Brazilian journal of medical and biological research, 2013-10, Vol.46 (10), p.839-843 [Periódico revisado por pares]

Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)

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Título:
The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice
Autor: Tristão, F S M ; Rocha, F A ; Dias, F C ; Rossi, M A ; Silva, J S
Assuntos: Animal experimentation ; Animals ; BIOLOGY ; Biomedical Sciences ; Development and progression ; Disease Models, Animal ; Distribution ; Health aspects ; Interferon-gamma - analysis ; Interleukin-10 - analysis ; Interleukin-4 - analysis ; Lung ; Lung - microbiology ; Lung Diseases, Fungal - microbiology ; Lungs ; Male ; MEDICINE, RESEARCH & EXPERIMENTAL ; Methods ; Mice ; Mice, Inbred C57BL ; Nitric Oxide - analysis ; Paracoccidioides ; Paracoccidioides brasiliensis ; Paracoccidioidomycosis ; Paracoccidioidomycosis - microbiology ; Physiological aspects ; Prognosis ; Time Factors
É parte de: Brazilian journal of medical and biological research, 2013-10, Vol.46 (10), p.839-843
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Paracoccidioidomycosis (PCM) is a chronic systemic mycosis caused by the inhalation of the thermally dimorphic fungus Paracoccidioides brasiliensis as well as the recently described P. lutzii. Because the primary infection occurs in the lungs, we investigated the differential involvement of the right and left lungs in experimental P. brasiliensis infection. Lungs were collected from C57BL/6 mice at 70 days after intravenous infection with 1×106 yeast cells of a virulent strain of P. brasiliensis (Pb18). The left lung, which in mice is smaller and has fewer lobes than the right lung, yielded increased fungal recovery associated with a predominant interleukin-4 response and diminished synthesis of interferon-γ and nitric oxide compared with the right lung. Our data indicate differential involvement of the right and left lungs during experimental PCM. This knowledge emphasizes the need for an accurate, standardized protocol for tissue collection during studies of experimental P. brasiliensis infection, since experiments using the same lungs favor the collection of comparable data among different mice.
Editor: Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)
Idioma: Inglês;Português

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The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice

Tristão, F S M ; Rocha, F A ; Dias, F C ; Rossi, M A ; Silva, J S

Brazil: Associacao Brasileira de Divulgacao Cientifica (ABDC)

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