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The effect immunoregulatory of galectin-1 on the experimental autoimmune uveitis (EAU)

A. G. Commodaro M Toscano; A Martin; L. D. V Moraes; H Serra; G Rabinovich; Luiz Vicente Rizzo; Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE (19. 2004 Águas de Lindóia, SP)

Resumos Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2004

Águas de Lindóia, São Paulo Federação de Sociedades de Biologia Experimental 2004

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  • Título:
    The effect immunoregulatory of galectin-1 on the experimental autoimmune uveitis (EAU)
  • Autor: A. G. Commodaro
  • M Toscano; A Martin; L. D. V Moraes; H Serra; G Rabinovich; Luiz Vicente Rizzo; Reunião Anual da Federação de Sociedades de Biologia Experimental, FeSBE (19. 2004 Águas de Lindóia, SP)
  • Assuntos: IMUNOLOGIA
  • É parte de: Resumos Águas de Lindóia, São Paulo: Federação de Sociedades de Biologia Experimental, 2004
  • Notas Locais: Disponível somente em CD-ROM
  • Descrição: Objetivo: Experimental autoimmune uveitis (EAU) is an organ specific T-cell mediated disease that targets the posterior pole of the eye. EAU can be induced in rodents and non-human primates through immunization with retinal antigens such as the interphotoreceptor retinoid-binding protein (IRBP). Alternative immunotherapeutic approaches to autoimmune uveitis are a major target of vision research, because the treatments available have numerous and severe side effects. Using the EAU model we have studied one such immunotherapeutic alternative. Métodos e Resultados: The B10.A mice were immunized s.c. with 100 mg of IRBP emulsified in CFA, plus 0,5 mg of Bordetella pertussis toxin in 0,1ml i.p. as an additional adjuvant. Animals were treated or not with 10mg of galectin-1 (GAL-1) i.p. in the afferent phase (2, 4 and 6 days post immunization-dpi) or efferent phase (14, 16 and 18 dpi). Lymph nodes were collected 21 days after immunization and cells were cultured to evaluate the proliferative responses to IRBP and determine cytokine synthesis. Delayed-type hypersensitivity responses to IRBP were calculated as the difference between the thickness of the IRBP-injected ear and the PBS-injected ear 48 hours after the injection of antigen. Disease severity was evaluated by histological examination of the enucleated eyes at day 21. GAL-1 was effective in modulating the level of structural damage to the retina and in inhibiting the proliferative and delayed-type
    hypersensitivity responses during the primary response to the antigen. Conclusões: These results are indicative of the possible therapeutic use of GAL-1 in autoimmune processes
  • Editor: Águas de Lindóia, São Paulo Federação de Sociedades de Biologia Experimental
  • Data de criação/publicação: 2004
  • Formato: res. 01.13.009.
  • Idioma: Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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