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Phagocytic uptake of fluorescent stealth and non-stealth solid lipid nanoparticles

Bocca, Claudia ; Caputo, Otto ; Cavalli, Roberta ; Gabriel, Ludovica ; Miglietta, Antonella ; Gasco, Maria Rosa

International journal of pharmaceutics, 1998-12, Vol.175 (2), p.185-193 [Periódico revisado por pares]

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Título:
Phagocytic uptake of fluorescent stealth and non-stealth solid lipid nanoparticles
Autor: Bocca, Claudia ; Caputo, Otto ; Cavalli, Roberta ; Gabriel, Ludovica ; Miglietta, Antonella ; Gasco, Maria Rosa
Assuntos: Biological and medical sciences ; Colloidal carriers ; General pharmacology ; Macrophages ; Medical sciences ; Phagocytosis uptake ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Stealth solid lipid nanoparticles
É parte de: International journal of pharmaceutics, 1998-12, Vol.175 (2), p.185-193
Descrição: Fluorescent non-stealth and stealth solid lipid nanoparticles (SLN) were prepared using rhodamine B base as fluorescent marker. The steric stabilization of the nanoparticles was obtained using two lipid derivatives of monomethylpoly(ethylene) glycol 2000 (PEG 2000) as stealth agents: dipalmitoylphosphatidylethanolamine-PEG 2000 and stearic acid-PEG 2000. Stealth and non-stealth SLN were in the nanometer size range. Phagocytosis was evaluated by incubating SLN with murine macrophages and determining the extent of phagocytic uptake spectrofluorimetrically; stealth SLN inhibited phagocytosis to a greater extent than did non-stealth SLN.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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