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Salbutamol: tablets, inhalational powder, or nebuliser?
Grimwood, K ; Johnson-Barrett, J J ; Taylor, B
BMJ, 1981-01, Vol.282 (6258), p.105-106
[Periódico revisado por pares]
England: British Medical Journal Publishing Group
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Título:
Salbutamol: tablets, inhalational powder, or nebuliser?
Autor:
Grimwood, K
;
Johnson-Barrett, J J
;
Taylor, B
Assuntos:
Aerosols
;
Albuterol - administration & dosage
;
Albuterol - therapeutic use
;
Asthma
;
Asthma - drug therapy
;
Bronchodilators
;
Child
;
Child, Preschool
;
Children
;
Clinical Trials as Topic
;
Dosage
;
Double-Blind Method
;
Female
;
Humans
;
Male
;
Nebulizers
;
Peak Expiratory Flow Rate
;
Placebos
;
Powders
;
Random Allocation
;
Sympathomimetics
;
Tablets
;
Writing tablets
É parte de:
BMJ, 1981-01, Vol.282 (6258), p.105-106
Notas:
istex:B6DC8D00794DA60C7966F4174E179E12C2471E03
href:bmj-282-105.pdf
local:bmj;282/6258/105
ark:/67375/NVC-KP1DKSRW-G
PMID:6779890
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-News-3
content type line 23
Descrição:
A study was carried out to ascertain the most effective method of giving salbutamol. Seventeen children with severe asthma received active salbutamol (4 mg via a nebuliser, 400 micrograms as an inhalational powder, or a 4 mg tablet) together with complementary placebos on a double-blind, triple-dummy randomly allocated basis. The bronchodilatation effect was assessed by measuring the peak expiratory flow rate. The bronchodilatation effect was greatest when patients received nebulised salbutamol (p less than 0.05) but lasted longest when they received the tablet (p less than 0.0001); the onset of the effect was rapid with all forms of administration. These results indicate that nebulised salbutamol gives the best relief in severe asthma; in less severe cases, however, a regimen combining the inhalational powder and tablets is sufficient and more convenient.
Editor:
England: British Medical Journal Publishing Group
Idioma:
Inglês
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