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Engineered nanoparticles: thrombotic events in cancer

Abdalla, Ahmed M. E ; Xiao, Lin ; Ouyang, Chenxi ; Yang, Guang

Nanoscale, 2014-11, Vol.6 (23), p.14141-14152 [Periódico revisado por pares]

England

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  • Título:
    Engineered nanoparticles: thrombotic events in cancer
  • Autor: Abdalla, Ahmed M. E ; Xiao, Lin ; Ouyang, Chenxi ; Yang, Guang
  • Assuntos: Contrast Media - adverse effects ; Contrast Media - chemistry ; Contrast Media - therapeutic use ; Humans ; Nanoparticles - adverse effects ; Nanoparticles - chemistry ; Neoplasms - diagnosis ; Thrombosis - diagnosis ; Thrombosis - etiology
  • É parte de: Nanoscale, 2014-11, Vol.6 (23), p.14141-14152
  • Notas: Ahmed M. E. Abdalla was awarded a Bachelor (honors) of Biochemistry in 2002 from the Juba University, Sudan. He finished his Master's degree in 2009 from the Faculty of Medicine, Gezira University, Sudan. In 2012, he started his PhD research at Huazhong University of Science and Technology, in the area of Biochemistry and Molecular Biology, where he is currently completing his candidature. His research interests include cancer-associated thrombosis and tumor cell lines.
    Lin Xiao received his BS degree in 2009 from Huazhong University of Science and Technology. He has been pursuing his PhD in biomaterial and tissue engineering in the same university under the supervision of Professor Guang Yang since 2010. From September 2011 to March 2013, he was a joint PhD student in McGill University under the supervision of Professor Adi Eisenberg. His research interests involve polylactic acid-based functional materials and multi-level assembly of amphiphilic block copolymers.
    Chenxi Ouyang is an associate professor in Wuhan Union Hospital and the editor-in-chief of the World Journal of Cardiovascular Surgery. He graduated in medicine from Tongji Medical College, Huazhong University of Science and Technology. He was then recruited to Hannover Medical University, Department of Cardial, Thoracical and Vascular Surgery, where he received his MD. He joined the vascular surgery staff at Wuhan Union Hospital, was awarded his PhD degree in General Surgery from Tongji Medical College and then contributed as a visiting associate professor at the Department of Biology in Stanford University, U.S.A. His research interests include cancer-associated thrombosis, artificial vascular grafts and tumor markers.
    Guang Yang is a Professor, a Distinguished Young Scholar, and a Chutian Scholar in Hubei Province. She received her BS and PhD degrees from Wuhan University. She was an Alexander von Humboldt fellow at Johannes Gutenberg-Universitaet Mainz, Germany (2002-2004) before moving to Kyushu University, Japan, as a Japan Society for the Promotion of Science fellow (2004-2006). She then moved to the College of Life Science and Technology at Huazhong University of Science and Technology as a professor. She was a senior visiting scholar at the University of Akron, USA in 2010. Her research interests focus on nanomedicine.
  • Descrição: Engineered nanoparticles are being increasingly produced for specific applications in medicine. Broad selections of nano-sized constructs have been developed for applications in diagnosis, imaging, and drug delivery. Nanoparticles as contrast agents enable conjugation with molecular markers which are essential for designing effective diagnostic and therapeutic strategies. Such investigations can also lead to a better understanding of disease mechanisms such as cancer-associated thrombosis which remains unpredictable with serious bleeding complications and high risk of death. Here we review the recent and current applications of engineered nanoparticles in diagnosis and therapeutic strategies, noting their toxicity in relation to specific markers as a target. Engineered nanoparticles are being increasingly produced for specific applications in medicine.
  • Editor: England
  • Idioma: Inglês
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