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Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer

Abdalla, Ahmed M. E. ; Xiao, Lin ; Miao, Yu ; Huang, Lixia ; Fadlallah, Gendeal M. ; Gauthier, Mario ; Ouyang, Chenxi ; Yang, Guang

Advanced science, 2020-05, Vol.7 (10), p.1903164-n/a [Periódico revisado por pares]

Germany: John Wiley & Sons, Inc

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  • Título:
    Nanotechnology Promotes Genetic and Functional Modifications of Therapeutic T Cells Against Cancer
  • Autor: Abdalla, Ahmed M. E. ; Xiao, Lin ; Miao, Yu ; Huang, Lixia ; Fadlallah, Gendeal M. ; Gauthier, Mario ; Ouyang, Chenxi ; Yang, Guang
  • Assuntos: Antigens ; cancer immunotherapy ; Cancer therapies ; Cell growth ; chimeric antigen receptor T cell therapy ; Cytokines ; Cytotoxicity ; Genes ; Genetic engineering ; Immunotherapy ; Lymphocytes ; Lymphoma ; Nanoparticles ; Nanotechnology ; Nervous system ; Patients ; Progress Report ; Progress Reports ; Stem cells ; T cell engineering ; Tumors ; Vectors (Biology)
  • É parte de: Advanced science, 2020-05, Vol.7 (10), p.1903164-n/a
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Growing experience with engineered chimeric antigen receptor (CAR)‐T cells has revealed some of the challenges associated with developing patient‐specific therapy. The promising clinical results obtained with CAR‐T therapy nevertheless demonstrate the urgency of advancements to promote and expand its uses. There is indeed a need to devise novel methods to generate potent CARs, and to confer them and track their anti‐tumor efficacy in CAR‐T therapy. A potentially effective approach to improve the efficacy of CAR‐T cell therapy would be to exploit the benefits of nanotechnology. This report highlights the current limitations of CAR‐T immunotherapy and pinpoints potential opportunities and tremendous advantages of using nanotechnology to 1) introduce CAR transgene cassettes into primary T cells, 2) stimulate T cell expansion and persistence, 3) improve T cell trafficking, 4) stimulate the intrinsic T cell activity, 5) reprogram the immunosuppressive cellular and vascular microenvironments, and 6) monitor the therapeutic efficacy of CAR‐T cell therapy. Therefore, genetic and functional modifications promoted by nanotechnology enable the generation of robust CAR‐T cell therapy and offer precision treatments against cancer. Herein, the current limitations of chimeric antigen receptor (CAR)‐T immunotherapy and potential opportunities and tremendous advantages of using nanotechnology to optimize CAR‐T cell therapy against cancer are highlighted. The genetic and functional modifications promoted by nanotechnology‐based strategies enable the generation of robust CAR‐T cell therapies and offer precision treatments against cancer.
  • Editor: Germany: John Wiley & Sons, Inc
  • Idioma: Inglês
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