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Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Brotherton, Paul ; Haak, Wolfgang ; Templeton, Jennifer ; Brandt, Guido ; Soubrier, Julien ; Jane Adler, Christina ; Richards, Stephen M ; Der Sarkissian, Clio ; Ganslmeier, Robert ; Friederich, Susanne ; Dresely, Veit ; van Oven, Mannis ; Kenyon, Rosalie ; Van der Hoek, Mark B ; Korlach, Jonas ; Luong, Khai ; Ho, Simon Y W ; Quintana-Murci, Lluis ; Behar, Doron M ; Meller, Harald ; Alt, Kurt W ; Cooper, Alan

Nature communications, 2013, Vol.4 (1), p.1764-1764, Article 1764 [Periódico revisado por pares]

England: Nature Publishing Group

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  • Título:
    Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
  • Autor: Brotherton, Paul ; Haak, Wolfgang ; Templeton, Jennifer ; Brandt, Guido ; Soubrier, Julien ; Jane Adler, Christina ; Richards, Stephen M ; Der Sarkissian, Clio ; Ganslmeier, Robert ; Friederich, Susanne ; Dresely, Veit ; van Oven, Mannis ; Kenyon, Rosalie ; Van der Hoek, Mark B ; Korlach, Jonas ; Luong, Khai ; Ho, Simon Y W ; Quintana-Murci, Lluis ; Behar, Doron M ; Meller, Harald ; Alt, Kurt W ; Cooper, Alan
  • Assuntos: ADN mitocondrial ; Base Sequence ; Demography ; European Continental Ancestry Group - genetics ; Europeus ; Evolution, Molecular ; Filogènia ; Genetics, Population ; Genoma humà ; Genome, Human - genetics ; Genome, Mitochondrial - genetics ; Haplotip ; Haplotypes - genetics ; Humans ; Molecular Sequence Data ; Neolític ; Phylogeny ; Principal Component Analysis ; Sequence Analysis, DNA ; Time Factors
  • É parte de: Nature communications, 2013, Vol.4 (1), p.1764-1764, Article 1764
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Members of The Genographic Consortium
    Syama Adhikarla, ArunKumar GaneshPrasad, Ramasamy Pitchappan, Arun Varatharajan Santhakumari Madurai Kamaraj University, Madurai, Tamil Nadu, India; Elena Balanovska, Oleg Balanovsky Research Centre for Medical Genetics, Russian Academy of Medical Sciences, Moscow, Russia; Jaume Bertranpetit, David Comas, Begoña Martínez-Cruz, Marta Melé, Universitat Pompeu Fabra, Barcelona, Spain; Andrew C. Clarke, Elizabeth A. Matisoo-Smith, University of Otago, Dunedin, New Zealand; Matthew C. Dulik, Jill B. Gaieski, Amanda C. Owings, Theodore G. Schurr, Miguel G. Vilar, University of Pennsylvania, Philadelphia, Pennsylvania, United States; Angela Hobbs, Himla Soodyall, National Health Laboratory Service, Johannesburg, South Africa; Asif Javed, Laxmi Parida, Daniel E. Platt, Ajay K. Royyuru, IBM, Yorktown Heights, New York, United States; Li Jin, Shilin Li, Fudan University, Shanghai, China; Matthew E. Kaplan, Nirav C. Merchant, University of Arizona, Tucson, Arizona, United States; R. John Mitchell, La Trobe University, Melbourne, Victoria, Australia; Lluis Quintana-Murci, Institut Pasteur, Paris, France; Colin Renfrew, University of Cambridge, Cambridge, United Kingdom; Daniela R. Lacerda, Fabrício R. Santos, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; David F. Soria Hernanz, R. Spencer Wells, National Geographic Society, Washington, District of Columbia, United States; Pandikumar Swamikrishnan, IBM, Somers, New York, United States; Chris Tyler-Smith, The Wellcome Trust Sanger Institute, Hinxton, United Kingdom; Pedro Paulo Vieira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Janet S. Ziegle, Applied Biosystems, Foster City, California, United States.
    Current address: Centre for Geogenetics, Natural History Museum of Denmark, 1350 Copenhagen, Denmark.
    P.B., W.H., and A.C. conceived and designed the project. P.B. designed and developed the DNA extraction, DNA library construction and hybridisation-based DNA-capture protocols (with assistance from J.T.). P.B., J.T., and W.H. generated and analysed the data. S.M.R., C.D., R.K., and M.B.v.d.H. contributed experimental steps and C.J.A., J.S., S.Y.W.H., J.K., and K.L. contributed analytical steps. G.B., R.G., S.F., V.D., M.v.O., L.Q., D.M.B., H.M., and K.W.A. provided ancient samples, contextual information, radiocarbon dating, and access to critical population data. P.B., W.H. and A.C. wrote the manuscript with input from C.J.A., J.S., S.Y.W.H., S.M.R., and J.K. All authors discussed the paper and gave comments.
    Current address: Institute of Dental Research, Westmead Centre for Oral Health, The University of Sydney, New South Wales 2145, Australia.
    Author contributions
  • Descrição: Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.
  • Editor: England: Nature Publishing Group
  • Idioma: Inglês
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