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Electrical Properties and Conduction in Reperfused Papillary Muscle

Cascio, Wayne E ; Yang, Hua ; Johnson, Timothy A ; Muller-Borer, Barbara J ; Lemasters, John J

Circulation research, 2001-10, Vol.89 (9), p.807-814 [Periódico revisado por pares]

Hagerstown, MD: American Heart Association, Inc

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Título:
Electrical Properties and Conduction in Reperfused Papillary Muscle
Autor: Cascio, Wayne E ; Yang, Hua ; Johnson, Timothy A ; Muller-Borer, Barbara J ; Lemasters, John J
Assuntos: Animals ; Biological and medical sciences ; Carbon Dioxide - metabolism ; Cardiology. Vascular system ; Cell Membrane - metabolism ; Coronary heart disease ; Electric Impedance ; Female ; Heart ; Heart Conduction System - physiology ; In Vitro Techniques ; Male ; Medical sciences ; Membrane Potentials - physiology ; Myocardial Contraction - physiology ; Myocardial Ischemia - physiopathology ; Myocardial Reperfusion ; Oxygen - metabolism ; Papillary Muscles - physiology ; Partial Pressure ; Potassium - metabolism ; Rabbits ; Recovery of Function - physiology ; Vascular Resistance - physiology
É parte de: Circulation research, 2001-10, Vol.89 (9), p.807-814
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The reversibility of ischemia-induced changes of extracellular K concentration ([K]o), resting membrane potential (EM), and passive cable-like properties, ie, extracellular resistance and cell-to-cell electrical coupling, and their relationship to recovery of conduction and contraction is described in 25 reperfused rabbit papillary muscles. No-flow ischemia caused extracellular K accumulation, depolarization of EM, an increase in whole-tissue (rt), external (ro), and internal (ri) longitudinal resistances, and failure of conduction and contraction. Muscles were reperfused 10 minutes after the onset of ischemia related cell-to-cell electrical uncoupling, ie, 26±1 minutes after arrest of perfusion. In 11 muscles, incomplete reflow occurred with only partial recovery of [K]o and rt. In the remaining 14 muscles, reperfusion caused a rapid and parallel decrease in [K]o, rt, and ro. When complete tissue reperfusion occurred, cell-to-cell electrical uncoupling was largely reversible. Thus, cell-to-cell electrical uncoupling did not indicate irreversible injury. Reperfusion induced a depolarizing current widening the difference between the K equilibrium potential and the EM. This difference decreased after longer periods of reperfusion. Conduction was restored and conduction velocity approached preischemic values as cell-to-cell electrical interaction was reestablished and EM recovered. The recovery of ro preceded ri, decreasing the ratio of the extracellular to intracellular resistance early in reperfusion, an effect predicted to influence the amplitude of the extracellular voltage field and electrocardiographic ST segments during reperfusion.
Editor: Hagerstown, MD: American Heart Association, Inc
Idioma: Inglês

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Electrical Properties and Conduction in Reperfused Papillary Muscle

Cascio, Wayne E ; Yang, Hua ; Johnson, Timothy A ; Muller-Borer, Barbara J ; Lemasters, John J

Hagerstown, MD: American Heart Association, Inc

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